This book constitutes the thoroughly refereed proceedings of the 8th International Conference on Mathematics and Computation in Music, MCM 2022, held in Atlanta, GA, USA, in June 2022. The 29 full papers and 8 short papers presented were carefully reviewed and selected from 45 submissions. The papers feature research that combines mathematics or computation with music theory, music analysis, composition, and performance. They are organized in Mathematical Scale and Rhythm Theory: Combinatorial, Graph Theoretic, Group Theoretic and Transformational Approaches; Categorical and Algebraic Approaches to Music; Algorithms and Modeling for Music and Music-Related Phenomena; Applications of Mathematics to Musical Analysis; Mathematical Techniques and Microtonality