Selected as a Doody's Core Title for 2022 and 2023! Covering all areas of trauma, critical care, and emergency surgery, The Trauma Manual: Trauma and Acute Care Surgery, 5th Edition, brings you fully up to date with recent changes in the field. This pocket manual is an indispensable resource for everyone on the trauma/acute care team, with practical, easy-to-read coverage of the wide range of patients seen daily with urgent presentation – whether from injury, emergency general surgical disease, or a major complication. This user-friendly manual is one that every trauma surgeon, surgical resident, surgical critical care specialist, emergency medicine physician, and emergency or trauma nurse will want to keep close at hand for daily use.   Up-to-date coverage of trauma, critical care, and emergency general surgery from a newly expanded group of national and international experts in the field. Organized in a chronological fashion following the usual events and phases of care after injury or acute surgical illness. Many new and revised chapters throughout the book, plus an entirely new section on surgical rescue and management of frequent complications. Evidence-based recommendations backed by extensive clinical experience, presented in a quick-reference format for ease of use. Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

Heme oxygenase is an enzyme which breaks down heme, the iron-containing oxygen-carrying constituent of the red blood cells. Heme must be synthesised and degraded within an individual nucleated cell, as heme is essential for the maintenance of cellular homeostasis by sensing or using oxygen. Physiological heme degradation is catalysed by the two functional isozymes of heme oxygenase, heme oxygenase-1 (HO-1) and HO-2, yielding CO, iron, and biliverdin IXN. Heme oxygenase-1 (HO-1), has potent anti-inflammatory, anti-oxidant and anti-proliferative effects, is up-regulated by multiple stimuli and provides protection against oxidative stress. HO-1 also plays an important role in the regulation of cardiovascular function and is involved in many other diseases such as sickle cell disease. This new book brings together leading research from around the world in this field.