This issue of Cardiac Electrophysiology Clinics, Guest Edited by Drs. Fermin C. Garcia, Luis C. Saenz, and Pasquale Santangeli, is dedicated to Intracardiac Echo Imaging in Atrial and Ventricular Arrhythmia Ablation. This is one of four issues selected each year by the series Consulting Editors, Ranjan K. Thakur and Andrea Natale. Topics include, but are not limited to: How to use intracardiac echography to recognize normal cardiac anatomy, Intracardiac echography to guide catheter ablation of ventricular arrhythmias in ischemic cardiomyopathy, Intracardiac echography to guide ablation of parahisian arrhythmias, Utility of ICE to guide transseptal catheterization for different EP procedures, Intracardiac echography to guide catheter ablation of atrial fibrillation, Role of intracardiac echography for transcatheter occlusion of left atrial appendage, Intracardiac echography to guide catheter ablation of idiopathic ventricular arrythmias, Intracardiac echography to guide catheter ablation of ventricular arrhythmias in non-ischemic cardiomyopathy, Intracardiac echography to guide mapping and ablation of arrhythmias in congenital heart disease patients, Prevention and early recognition of complications during catheter ablation by Intracardiac echography, Intracardiac echography to evaluate radiofrequency lesion creation and Image integration using intracardiac echography and 3-D reconstruction for mapping and ablation of atrial and ventricular arrhythmias.

This book features a collection of high-quality research papers presented at the International Conference on Tourism, Technology & Systems (ICOTTS 2020), held at the University of Cartagena, in Cartagena de Indias, Colombia, from 29th to 31st October 2020. The book is divided into two volumes, and it covers the areas of technology in tourism and the tourist experience, generations and technology in tourism, digital marketing applied to tourism and travel, mobile technologies applied to sustainable tourism, information technologies in tourism, digital transformation of tourism business, e-tourism and tourism 2.0, big data and management for travel and tourism, geotagging and tourist mobility, smart destinations, robotics in tourism, and information systems and technologies.

This volume describes the more relevant secondary metabolites of different fungi with current information on their biosynthesis and molecular genetics. Bolstered with color illustrations and photographs, the book describes the possible application of molecular genetics to directed strain improvement in great detail. The needs for future developments in this field are also discussed at length

Written by authorities in the field, "Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites" provides a cutting-edge perspective on fungal secondary metabolism and underlying genetics and is a valuable resource for scientists, researchers, and educators in the field of fungal biology.

This book contains the revised and extended versions of selected conference communications, representing the state-of-the-art in the advances on computational multibody models, from the most abstract mathematical developments to practical engineering applications. This book will be highly valuable for experienced researchers that want to keep updated on the details of the latest driving ideas in this field, but also to researchers approaching the field for the first time, since it provides a useful overview of the most active areas and the efforts devoted by many prominent research groups worldwide.

Soil enzymes play a fundamental role in many soil processes such as the mineralization of organic matter, the synthesis of humic substances, the degradation of xenobiotics or the mechanisms involved in the biocontrol of plant pathogens. Their direct link with soil microorganisms gives them a key role as biomonitors of the evolution of soil quality or in the monitoring of the application of organic amendments to degraded soils. As a consequence of the importance of soil enzymes on soil processes, there is an increasing interest in their study, as well as in the application of molecular techniques as diagnostic tools.

The First International Symposium on the Education in Mechanism and Machine Science (ISEMMS 2013) aimed to create a stable platform for the interchange of experience among researches of mechanism and machine science.
Topics treated include contributions on subjects such as new trends and experiences in mechanical engineering education; mechanism and machine science in mechanical engineering curricula; MMS in engineering programs, such as, for example, methodology, virtual labs and new laws.
All papers have been rigorously reviewed and represent the state of the art in their field.

Fungi produce many chemically diverse secondary metabolites whose biological roles largely remain elusive. Within the increasing number of sequenced fungal genomes several important genes involved in secondary metabolite formation have been identified. Most of these genes are clustered and their coordinated transcription is controlled in a complex way by both narrow pathway-specific regulators as well as broad global transcription factors responsive to environmental cues. In recent years it was discovered many of the newly identified gene clusters are silent under laboratory conditions suggesting that the biosynthetic potential of fungi is far from being exploited. Besides identifying novel bioactive metabolites from still unexplored sources, the activation of these gene clusters by several approaches may result in the discovery of new substances with antibiotic and pharmaceutical benefits. This book covers recent advances in the field of fungal secondary metabolisms ranging from methodologies to biological aspects and will include the latest knowledge on fungal molecular biology, genomics, and metabolomics. With the related volume by Professor Juan-Francisco Martin, where the most relevant and well-studied fungal secondary metabolites are compiled, this book provides a comprehensive overview of the state-of-the-art of research on fungal secondary metabolites.

In this issue, guest editors bring their considerable expertise to this important topic. Provides in-depth reviews on the latest updates in the field, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize

This book describes the three gasotransmitters nitric oxide (NO), hydrogen sulphide (H2S) and carbon monoxide (CO) and their function as intracellular signalling molecules in plants. Common properties are shared by NO, H2S and CO: they are beneficial at low concentrations but hazardous in higher amounts; they are small molecules of gas; they can freely cross cell membranes; their effects do not rely on receptors; they are generated enzymatically and their production is regulated; their functions can be mimicked by exogenous application; and their cellular effects may or may not be mediated by second messengers, but have specific cellular and molecular targets. In plants, many aspects of the biology of gasotransmitters remain completely unknown and generate intriguing questions, which will be discussed in this book.

This book features a collection of high-quality research papers presented at the International Conference on Tourism, Technology & Systems (ICOTTS 2021), held at the University of Cartagena, in Cartagena de Indias, Colombia, from 4 to 6 November 2021. The book is divided into two volumes, and it covers the areas of technology in tourism and the tourist experience, generations and technology in tourism, digital marketing applied to tourism and travel, mobile technologies applied to sustainable tourism, information technologies in tourism, digital transformation of tourism business, e-tourism and tourism 2.0, big data and management for travel and tourism, geotagging and tourist mobility, smart destinations, robotics in tourism, and information systems and technologies.

Austin's words on page 1 of his seminal work How to do things with words are valid for this study on clause typing in the Old Irish verbal complex: "The phenomenon to be discussed is very widespread and obvious, and it cannot fail to have been already noticed, at least here and there, by others. Yet I have not found attention paid to it specifically". Old Irish, a regular V1 language, morphologically distinguishes six clause types, to wit, declarative, relative, wh- and polar interrogative, responsive and imperative clause types. After discussing the constituency of the Old Irish verbal complex and the pragmatically marked orders, i.e. cleft-sentence and left-dislocation, the form, function, paradigmatic consistency and syntax of those clause types are then analysed in detail. The other main issues of this study are the descriptively adequate paradigm of clause types and the interaction of clause typing with subordination and with non-verbal predication in Old Irish. This monograph offers a comprehensive view of clause typing, its morphological expression and related phenomena in the earliest Insular Celtic language, and may also contribute to the general consideration of these topics in both the typological and diachronic perspectives.

Soils have been called the most complex microbial ecosystems on Earth. A single gram of soil can harbor millions of microbial cells and thousands of species. However, certain soil environments, such as those experiencing dramatic change exposing new initial soils or that are limited in precipitation, limit the number of species able to survive in these systems. In this respect, these environments offer unparalleled opportunities to uncover the factors that control the development and maintenance of complex microbial ecosystems. This book collects chapters that discuss the abiotic factors that structure arid and initial soil communities as well as the diversity and structure of the biological communities in these soils from viruses to plants.

Recent changes in the pattern of agricultural practices from use of hazardous pesticides to natural (organic) cultivation has brought into focus the use of agriculturally important microorganisms for carrying out analogous functions. The reputation of plant growth promoting rhizomicroorganisms (PGPRs) is due to their antagonistic mechanisms against most of the fungal and bacterial phytopathogens. The biocontrol potential of agriculturally important microorganisms is mostly attributed to their bioactive secondary metabolites. However, low shelf life of many potential agriculturally important microorganisms impairs their use in agriculture and adoption by farmers. The focal theme of this book is to highlight the potential of employing biosynthesized secondary metabolites (SMs) from agriculturally important microorganisms for management of notorious phytopathogens, as a substitute of the currently available whole organism formulations and also as alternatives to hazardous synthetic pesticides. Accordingly, we have incorporated a comprehensive rundown of sections which particularly examine the SMs synthesized, secreted and induced by various agriculturally important microorganisms and their applications in agriculture. Section 1 includes discussion on biosynthesized antimicrobial secondary metabolites from fungal biocontrol agents. This section will cover the various issues such as development of formulation of secondary metabolites, genomic basis of metabolic diversity, metabolomic profiling of fungal biocontrol agents, novel classes of antimicrobial peptides. The section 1 will also cover the role of these secondary metabolites in antagonist-host interaction and application of biosynthesized antimicrobial secondary metabolites for management of plant diseases. Section 2 will discuss the biosynthesized secondary metabolites from bacterial PGPRs, strain dependent effects on plant metabolome profile, bio-prospecting various isolates of bacterial PGPRs for potential secondary metabolites and non-target effects of PGPR on microbial community structure and functions. Section 3 encompasses synthesis of antimicrobial secondary metabolites from beneficial endophytes, bio-prospecting medicinal and aromatic hosts and effect of endophytic SMs on plants under biotic and biotic stress conditions.

The Future of Soil Carbon: Its Conservation and Formation provides readers with an integrative approach to understanding the important role of organic carbon in soil functioning and fertility. Terrestrial interactions between SOC and complex human-natural systems require new fundamental and applied research into regional and global SOC budgets. This book provides new and synthesized information on the dynamics of SOC in the terrestrial environment. In addition to rigorous state-of-the art on soil science, the book also provides strategies to avoid risks of soil carbon losses. Soil organic carbon (SOC) is a vital component of soils, with important and far-reaching effects on the functioning of terrestrial ecosystems. Human activities over the last several decades have significantly changed the regional and global balance of SOC, greatly exacerbating global warming and climate change.

Popper's theory of science has been widely misunderstood and poorly represented in the literature on philosophy of science, over the last three decades. This book discusses the main issues in Popper's theory of science and, after giving a careful characterization of each issue, examines the main objections that have been raised against them and offers ways of circumventing them. It demonstrates that Popper's theory can guide us again to a better understanding of the aim and the structure of science.

This book describes the three gasotransmitters nitric oxide (NO), hydrogen sulphide (H2S) and carbon monoxide (CO) and their function as intracellular signalling molecules in plants. Common properties are shared by NO, H2S and CO: they are beneficial at low concentrations but hazardous in higher amounts; they are small molecules of gas; they can freely cross cell membranes; their effects do not rely on receptors; they are generated enzymatically and their production is regulated; their functions can be mimicked by exogenous application; and their cellular effects may or may not be mediated by second messengers, but have specific cellular and molecular targets. In plants, many aspects of the biology of gasotransmitters remain completely unknown and generate intriguing questions, which will be discussed in this book.

Advanced nanostructured materials such as organic and inorganic micro/nanostructures are excellent building blocks for electronics, optoelectronics, sensing, and photovoltaics because of their high-crystallinity, long aspect-ratio, high surface-to-volume ratio, and low dimensionality. However, their assembly over large areas and integration in functional circuits are a matter of intensive investigation. This Element provides detailed description of various technologies to realize micro/nanostructures based large-area electronics (LAE) devices on rigid or flexible/stretchable substrates. The first section of this Element provides an introduction to the state-of-the-art integration techniques used to fabricate LAE devices based on different kind of micro/nanostructures. The second section describes inorganic and organic micro/nanostructures, including most common and promising synthesis procedures. In the third section,different techniques are explained that have great potential for integration of micro/nanostructures over large areas. Finally, the fourth section summarizes important remarks about LAE devices based on micro/nanostructures, and future directions.

Fungi produce many chemically diverse secondary metabolites whose biological roles largely remain elusive. Within the increasing number of sequenced fungal genomes several important genes involved in secondary metabolite formation have been identified. Most of these genes are clustered and their coordinated transcription is controlled in a complex way by both narrow pathway-specific regulators as well as broad global transcription factors responsive to environmental cues. In recent years it was discovered many of the newly identified gene clusters are silent under laboratory conditions suggesting that the biosynthetic potential of fungi is far from being exploited. Besides identifying novel bioactive metabolites from still unexplored sources, the activation of these gene clusters by several approaches may result in the discovery of new substances with antibiotic and pharmaceutical benefits. This book covers recent advances in the field of fungal secondary metabolisms ranging from methodologies to biological aspects and will include the latest knowledge on fungal molecular biology, genomics, and metabolomics. With the related volume by Professor Juan-Francisco Martin, where the most relevant and well-studied fungal secondary metabolites are compiled, this book provides a comprehensive overview of the state-of-the-art of research on fungal secondary metabolites.