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Showing 1 - 11 of 11 matches in All departments

The LEGO Movie (English & Foreign language, Blu-ray disc): Chris Pratt, Elizabeth Banks, Will Arnett, Morgan Freeman, Will... The LEGO Movie (English & Foreign language, Blu-ray disc)
Chris Pratt, Elizabeth Banks, Will Arnett, Morgan Freeman, Will Ferrell, … 1
R57 Discovery Miles 570 Ships in 20 - 25 working days

Chris Pratt, Elizabeth Banks, Will Arnett and Morgan Freeman lend their voices to this CGI-animated comedy based on the line of toys made by Lego. The wicked Lord Business (Will Ferrell) is determined to destroy the Lego universe and rebuild it using glue - which goes against the very nature of Lego. Mistaken as the 'Special', the only surviving Master Builder, the rather ordinary Emmet (Pratt) is selected to lead a group of figures on a mission to put a stop to Lord Business's evil plan. Emmet is helped by wise wizard Vitruvius (Freeman), tough girl Wyldstyle (Banks) and DC superhero Batman (Arnett), but can he find something extraordinary within himself in order to save the world? The film also features the voices of Channing Tatum, Liam Neeson, Nick Offerman, Alison Brie and Jonah Hill. The film won a BAFTA for Best Animated Film and was nominated for Best Original Song at the Oscars.

Sherlock Holmes (DVD): Robert Downey Jr., Jude Law, Rachel McAdams, Mark Strong, Kelly Reilly, Eddie Marsan, James Fox, Hans... Sherlock Holmes (DVD)
Robert Downey Jr., Jude Law, Rachel McAdams, Mark Strong, Kelly Reilly, … 2
R60 R46 Discovery Miles 460 Save R14 (23%) Ships in 20 - 25 working days

The great Victorian detective returns in this action thriller directed by Guy Ritchie and starring Robert Downey Jr (in a Golden Globe-winning performance), Jude Law, Rachel McAdams and Mark Strong. Based on a new story by producer Lionel Wigram using Arthur Conan Doyle's famous characters, the film follows Sherlock Holmes (Downey Jr) and his loyal assistant Dr Watson (Law) as they deal with a mysterious new nemesis: Lord Blackwood (Strong), a cult leader and Satanist who harbours the most deadly of intentions. Abandoning the accepted portrayals of Holmes and Watson, as perfected by Basil Rathbone and Nigel Bruce in the films of the 1930s and '40s, Downey Jr's Holmes is a modern, bohemian man of action and intellect, while Law's Watson is no longer the bumbling fool of old, but a much sharper character with an eye for the ladies and a taste for gambling.

The LEGO Movie (English, Hindi, Portuguese, DVD): Chris Pratt, Elizabeth Banks, Will Arnett, Morgan Freeman, Will Ferrell,... The LEGO Movie (English, Hindi, Portuguese, DVD)
Chris Pratt, Elizabeth Banks, Will Arnett, Morgan Freeman, Will Ferrell, … 1
R125 Discovery Miles 1 250 Ships in 10 - 15 working days

Chris Pratt, Elizabeth Banks, Will Arnett and Morgan Freeman lend their voices to this CGI-animated comedy based on the line of toys made by Lego. The wicked Lord Business (Will Ferrell) is determined to destroy the Lego universe and rebuild it using glue - which goes against the very nature of Lego. Mistaken as the 'Special', the only surviving Master Builder, the rather ordinary Emmet (Pratt) is selected to lead a group of figures on a mission to put a stop to Lord Business's evil plan. Emmet is helped by wise wizard Vitruvius (Freeman), tough girl Wyldstyle (Banks) and DC superhero Batman (Arnett), but can he find something extraordinary within himself in order to save the world? The film also features the voices of Channing Tatum, Liam Neeson, Nick Offerman, Alison Brie and Jonah Hill.

Sherlock Holmes: A Game of Shadows (DVD): Robert Downey Jr., Rachel McAdams, Noomi Rapace, Jude Law, Stephen Fry, Jared Harris,... Sherlock Holmes: A Game of Shadows (DVD)
Robert Downey Jr., Rachel McAdams, Noomi Rapace, Jude Law, Stephen Fry, …
R104 Discovery Miles 1 040 Ships in 10 - 15 working days

Robert Downey Jr and Jude Law reprise their roles as Sherlock Holmes and Dr Watson in Guy Ritchie's second adaptation of the classic Arthur Conan Doyle detective novels. When the Crown Prince of Austria is found dead, Inspector Lestrade (Eddie Marsan) pronounces suicide as the cause of death. But Sherlock Holmes deduces that the prince has been murdered - and is soon untangling an international web of intrigue, in which all threads appear to lead to criminal mastermind Professor Moriarty (Jared Harris). The supporting cast includes Stephen Fry, Kelly Reilly, Geraldine James and Noomi Rapace.

Gangster Squad (English & Foreign language, Blu-ray disc): Ryan Gosling, Emma Stone, Sean Penn, Josh Brolin, Michael Peņa,... Gangster Squad (English & Foreign language, Blu-ray disc)
Ryan Gosling, Emma Stone, Sean Penn, Josh Brolin, Michael Peņa, … 1
R196 Discovery Miles 1 960 Ships in 10 - 15 working days

Crime drama set in the 1940s and '50s in Los Angeles inspired by the real life story of vicious mob boss Mickey Cohen and the LAPD officers who tried to bring him down. After moving to LA from the East Coast, Cohen (Sean Penn) has taken control of the town. A force to be reckoned with, he not only has his gang to do his bidding but a number of policemen and politicians are also under his command. Police Chief Bill Parker (Nick Nolte) instructs Sergeant John O'Mara (Josh Brolin) to wage war against Cohen and his men. With only a small squad which includes his colleague, Jerry Wooters (Ryan Gosling), O'Mara attempts to regain control of the city. Meanwhile, Wooters gets involved with the mobster's girlfriend, Grace Faraday (Emma Stone), which, if discovered, will only serve to enrage Cohen further.

The Invention of Lying (Blu-ray disc): Jonah Hill, Jennifer Garner, Jason Bateman, Tina Fey, Ricky Gervais, Louis C K, Jeffrey... The Invention of Lying (Blu-ray disc)
Jonah Hill, Jennifer Garner, Jason Bateman, Tina Fey, Ricky Gervais, …
R143 Discovery Miles 1 430 Ships in 10 - 15 working days

Comedy directed by, co-written by and starring Ricky Gervais as Mark, a performer who tells the first lie in a world where people only tell the truth and lying has never before existed. Once he realises what he can achieve by lying, there is no stopping him. He uses his new found ability to advance his career and charm the girl of his dreams, Jennifer (Jennifer Garner) - who is completely out of his league - to much comic effect.

Gangster Collection (DVD): Ben Affleck, Rebecca Hall, Blake Lively, Jeremy Renner, Jon Hamm, Michael Caine, Britt Ekland, Ian... Gangster Collection (DVD)
Ben Affleck, Rebecca Hall, Blake Lively, Jeremy Renner, Jon Hamm, …
R168 Discovery Miles 1 680 Out of stock

Collection of four gangster dramas. In 'The Town' (2010) Ben Affleck directs and stars as Doug MacRay, one of four Boston criminals who rob a bank. Doug falls for the bank's manager, Claire (Rebecca Hall), who is distressed after the robbery and begins dating her. With Claire unaware that Doug was one of the robbers, their relationship continues while Doug plans his next job and Claire co-operates with the FBI. Can Doug keep up the facade or will the law finally catch up with him? In 'Get Carter' (1971) Michael Caine stars as a hardened gangster returning to his home town in search of the truth behind his brother's death. Though originally from Newcastle, Jack Carter (Caine) has made his name in London as a tough enforcer for crime boss Gerald Fletcher (Terence Rigby). On hearing of his brother's death, Carter returns to Newcastle for his funeral and to investigate his suspicion that his sibling may have been murdered. After visiting local gangster Cyril Kinnear (John Osborne), Carter is threatened and advised to head back to London. Jack refuses and descends further and further into the city's underworld as his investigations begin to pay off. His search is merciless, unrelenting and fraught with danger and it becomes clear that he will stop at nothing to exact his own brand of justice. 'Gangster Squad' (2013) is set in the 1940s and '50s in Los Angeles and is inspired by the real life story of vicious mob boss Mickey Cohen and the LAPD officers who tried to bring him down. After moving to LA from the East Coast, Cohen (Sean Penn) has taken control of the town. A force to be reckoned with, he not only has his gang to do his bidding but a number of policemen and politicians are also under his command. Police Chief Bill Parker (Nick Nolte) instructs Sergeant John O'Mara (Josh Brolin) to wage war against Cohen and his men. With only a small squad which includes his colleague, Jerry Wooters (Ryan Gosling), O'Mara attempts to regain control of the city. Meanwhile, Wooters gets involved with the mobster's girlfriend, Grace Faraday (Emma Stone), which, if discovered, will only serve to enrage Cohen further. 'Goodfellas' (1990), directed by Martin Scorsese, follows Henry Hill (Ray Liotta) as he rises through the ranks of the Mafia. Upon turning FBI informant to help pay for his drug addiction, Hill recalls how he got started in the Mob following the six million dollar robbery of a Lufthansa cargo at a New York airport. Hill and his partners, Jimmy Conway (Robert De Niro) and Tommy DeVito (Joe Pesci), went on to rise through the ranks of the Mafia over three decades, eventually eliminating Paul Cicero (Paul Sorvino), the neighbourhood godfather who originally took Hill under his wing.

The World in Guangzhou - Africans and Other Foreigners in South China's Global Marketplace (Paperback): Gordon Mathews,... The World in Guangzhou - Africans and Other Foreigners in South China's Global Marketplace (Paperback)
Gordon Mathews, Linessa Dan Lin, Yang Yang
R541 Discovery Miles 5 410 Ships in 10 - 15 working days

Mere decades ago, the population of Guangzhou was almost wholly Chinese. Today, it is a truly global city, a place where people from around the world go to make new lives, find themselves, or further their careers. A large number of those migrants are small-scale traders from Africa who deal in Chinese goods often knock-offs or copies of high-end branded items to send back to their home countries. In The World in Guangzhou, Gordon Mathews explores the question of how the city became such a center of "low-end" globalization and shows what we can learn from that experience similar transformations elsewhere in the world. Through detailed ethnographic portraits, Mathews reveals a world of globalization based on informality, reputation, and trust rather than on formal contracts. How, he asks, can such informal relationships emerge between two groups Chinese and Sub-Saharan Africans that don't share a common language, culture, or religion? And what happens when Africans move beyond their status as temporary residents and begin to put down roots and establish families? Full of unforgettable characters, The World in Guangzhou presents a compelling account of globalization at ground level and offers a look into the future of urban life as transnational connections continue to remake cities around the world.

Sherlock Holmes (Blu-ray disc): Robert Downey Jr., Jude Law, Rachel McAdams, Mark Strong, Kelly Reilly, Eddie Marsan, James... Sherlock Holmes (Blu-ray disc)
Robert Downey Jr., Jude Law, Rachel McAdams, Mark Strong, Kelly Reilly, …
R189 Discovery Miles 1 890 Ships in 10 - 15 working days

The great Victorian detective returns in this action thriller directed by Guy Ritchie and starring Robert Downey Jr (in a Golden Globe-winning performance), Jude Law, Rachel McAdams and Mark Strong. Based on a new story by producer Lionel Wigram using Arthur Conan Doyle's famous characters, the film follows Sherlock Holmes (Downey Jr) and his loyal assistant Dr Watson (Law) as they deal with a mysterious new nemesis: Lord Blackwood (Strong), a cult leader and Satanist who harbours the most deadly of intentions. Abandoning the accepted portrayals of Holmes and Watson, as perfected by Basil Rathbone and Nigel Bruce in the films of the 1930s and '40s, Downey Jr's Holmes is a modern, bohemian man of action and intellect, while Law's Watson is no longer the bumbling fool of old, but a much sharper character with an eye for the ladies and a taste for gambling.

The World in Guangzhou - Africans and Other Foreigners in South China?s Global Marketplace (Hardcover): Gordon Mathews, Linessa... The World in Guangzhou - Africans and Other Foreigners in South China?s Global Marketplace (Hardcover)
Gordon Mathews, Linessa Dan Lin, Yang Yang
R1,686 Discovery Miles 16 860 Out of stock

Mere decades ago, the population of Guangzhou was almost wholly Chinese. Today, it is a truly global city, a place where people from around the world go to make new lives, find themselves, or further their careers. A large number of those migrants are small-scale traders from Africa who deal in Chinese goods often knock-offs or copies of high-end branded items to send back to their home countries. In The World in Guangzhou, Gordon Mathews explores the question of how the city became such a center of "low-end" globalization and shows what we can learn from that experience similar transformations elsewhere in the world. Through detailed ethnographic portraits, Mathews reveals a world of globalization based on informality, reputation, and trust rather than on formal contracts. How, he asks, can such informal relationships emerge between two groups Chinese and Sub-Saharan Africans that don't share a common language, culture, or religion? And what happens when Africans move beyond their status as temporary residents and begin to put down roots and establish families? Full of unforgettable characters, The World in Guangzhou presents a compelling account of globalization at ground level and offers a look into the future of urban life as transnational connections continue to remake cities around the world.

Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R - Order-Restricted Analysis of Microarray... Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R - Order-Restricted Analysis of Microarray Data (Paperback, 2012)
Dan Lin, Ziv Shkedy, Daniel Yekutieli, Dhammika Amaratunga, Luc Bijnens
R1,087 Discovery Miles 10 870 Out of stock

This book focuses on the analysis of dose-response microarray data in pharmaceutical settings, the goal being to cover this important topic for early drug development experiments and to provide user-friendly R packages that can be used to analyze this data. It is intended for biostatisticians and bioinformaticians in the pharmaceutical industry, biologists, and biostatistics/bioinformatics graduate students.

Part I of the book is an introduction, in which we discuss the dose-response setting and the problem of estimating normal means under order restrictions. In particular, we discuss the pooled-adjacent-violator (PAV) algorithm and isotonic regression, as well as inference under order restrictions and non-linear parametric models, which are used in the second part of the book.

Part II is the core of the book, in which we focus on the analysis of dose-response microarray data. Methodological topics discussed include:

Multiplicity adjustment

Test statistics and procedures for the analysis of dose-response microarray data

Resampling-based inference and use of the SAM method for small-variance genes in the data

Identification and classification of dose-response curve shapes

Clustering of order-restricted (but not necessarily monotone) dose-response profiles

Gene set analysis to facilitate the interpretation of microarray results

Hierarchical Bayesian models and Bayesian variable selection

Non-linear models for dose-response microarray data

Multiple contrast tests

Multiple confidence intervals for selected parameters adjusted for the false coverage-statement rate

All methodological issues in the book are illustrated using real-world examples of dose-response microarray datasets from early drug development experiments.

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