International researchers summarize the current understanding of peptic disease and trace the development of a novel new drug for peptic disease therapy-sucralfate. Contributors present laboratory research along side data from clinical trials as well as from the practice of medicine. Articles discuss the history of sucralfate's development, mechanisms of action, clinical efficacy, and future directions for research. This volume will be of interest to scientists and clinicians working in gastroenterology and gastrointestinal physiology.

Ocean and coastal management regimes are increasingly subject to competing demands from stakeholders. Regulations must not only address fishing, recreation, and shipping, but also sand and gravel mining, gas pipelines, harbor/port development, offshore wind and tidal energy facilities, liquefied natural gas terminals, offshore aquaculture, and desalinization plants. The growing variety and intensity of ocean and coastal uses increases the call for a more holistic, comprehensive, and coordinated management approach that recognizes the often complex relationships between natural and human systems. For both economist and non-economist audiences, this book describes ways in which economic analysis can be an important tool to inform and improve ecosystem-based management (EBM). Topics include modeling economic impacts, benefit-cost analysis, spatial considerations in EBM, incentives and human behaviors, and accounting for uncertainty in policy analysis. Throughout the book the authors elucidate the different kinds of insights which can be gained from the use of different economic tools. In this rigorous and accessible work, the authors defy the conventional stereotype that economic perspectives necessarily favor the greatest commercial development. Instead, they demonstrate how comprehensive economic analyses consider the full range of potential services offered by marine and coastal ecosystems, including the conservation of biodiversity and creation of recreational opportunities.

Ocean and coastal management regimes are increasingly subject to competing demands from stakeholders. Regulations must not only address fishing, recreation, and shipping, but also sand and gravel mining, gas pipelines, harbor/port development, offshore wind and tidal energy facilities, liquefied natural gas terminals, offshore aquaculture, and desalinization plants. The growing variety and intensity of ocean and coastal uses increases the call for a more holistic, comprehensive, and coordinated management approach that recognizes the often complex relationships between natural and human systems. For both economist and non-economist audiences, this book describes ways in which economic analysis can be an important tool to inform and improve ecosystem-based management (EBM). Topics include modeling economic impacts, benefit-cost analysis, spatial considerations in EBM, incentives and human behaviors, and accounting for uncertainty in policy analysis. Throughout the book the authors elucidate the different kinds of insights which can be gained from the use of different economic tools. In this rigorous and accessible work, the authors defy the conventional stereotype that economic perspectives necessarily favor the greatest commercial development. Instead, they demonstrate how comprehensive economic analyses consider the full range of potential services offered by marine and coastal ecosystems, including the conservation of biodiversity and creation of recreational opportunities.

Gastric secretions contain hydrogen ions at a concentration that is more than one million times higher than their intracellular concentration. This phenomenal gradient as well as the demonstrated ability of gastric juice to digest tissues has motivated clinicians and investigators alike to emphasize acid secretion and acid ablation in studying the pathogenesis and therapy of peptic ulcer disease. Conse quently, over the past 150 years, we have made considerable progress in under standing the mechanisms and regulation of acid secretion by the stomach. Not surprisingly, therapy for both peptic disease and mucosal injury has also been predominantly directed at either neutralizing acid or suppressing its production. During the past 10 years, attention has been focused on factors other than acid in the genesis and therapy of ulcer disease. Work done worldwide demon strated that acid hypersecretion is not a common event in peptic ulcer disease. Therefore, we began realizing that factors other than acid secretion may be important in the genesis of ulcer disease or in gastroduodenal mucosal damage. In addition, new physiological information has established that the gas troduodenal mucosa is normally protected by a complex series of events includ ing mucus and bicarbonate secretion, cell renewal, surface mucosal restitution, and preservation of the microvasculature and mucosal proliferative zone.

International researchers summarize the current understanding of peptic disease and trace the development of a novel new drug for peptic disease therapy-sucralfate. Contributors present laboratory research along side data from clinical trials as well as from the practice of medicine. Articles discuss the history of sucralfate's development, mechanisms of action, clinical efficacy, and future directions for research. This volume will be of interest to scientists and clinicians working in gastroenterology and gastrointestinal physiology.

While Daniel Holland’s memoir details his involvement in the draft resistance movement of the 1960s, the impetus to share his story now comes from the dangerous new president and congress that have taken control of the United States and threaten to plunge our nation into war. People of age to fight in today's conflicts were not yet born when the lessons of Vietnam were being learned, so this book may serve as a guide to the decisions they face in this contemporary, volatile world. Holland alternates chapters about the breaking news of the time with personal memories and reflections on his own coming of age, portraying a growing consciousness and an evolution of youthful naivete into committed antiwar activism. Then his focus turns to the legal adventures that follow: indictment, arrest, arraignment, defending himself at trial, and sentencing. Holland also shares episodes of draft board raids, secret rooms, and the day-to-day responsibilities of a full-time activist. He follows a surprise ending with a thoughtful afterword contemplating our personal responsibilities for peace.