The field of pediatric oncology encompasses four groups of malignancies - acute leukemias, brain tumors, lymphomas and solid tumors. 1'he history, diagnosis and management of children with acute leukemias and lymphomas has been thoroughly examined in several excellent textbooks of pediatric hematology and oncology. Bl"ain tumors have historically been managed by neurosurgeons and radiation therapists. 1'he role of the pediatric oncologist in the management of these patients is evolving. This book was written to provide a thorough historical evaluation of the most frequent solid tumors of children. A detailed examination of the natural history of these tumors is essential to the design and evaluation of therapeutic trials. The highly lethal nature of many of these tumors, the occurrence of some of them at several different primary sites and the rarity of these tumors have made systematic study of them difficult. Conclusions regarding the efficacy of a particular modification of the therapeutic strategy can be strongly influenced by the assumed natural history of the tumor. I have tried to develop as accurateJy as the literature would allow a picture of the natural history of the common malignant solid tumors, knowing that the image would be imperfect. I adopted a convention which was employed in all graphs constructeil from case reports summarized from the literature.

This edited volume presents a new, grand and global narrative for international relations (IR) history in the pivotal nineteenth century. Typically considered by IR scholars to be a long century of relative peace after 1815, the contributors offer a reconceptualization of IR in this century, arguing that it is temporally bifurcated, with very different patterns of behavior in the first and second halves. A mid-century discontinuity - a "pivot period" - marks the transition phase in Europe and globally when, in the space of a few years, a shift occurred from a comparatively calm, politically disconnected world under loose British free trade hegemony to one of scrambles for territory and keen interest in imperial possessions and conquest. All the book's chapters deal with characterizing patterns of relations in the first half of the century or the second, with two addressing the discontinuity in the middle. In the first half aspects of regional orders are described (in Latin America, East Asia and Europe) alongside crucial developmental processes (missionaries and colonial expansion, the agency of regionally localized actors, of leading elites). In the second half, there is again discussion of regional developments (East Asia, Europe), but now under the onslaught and pressures of the latter half of the century, and spotlighting industrialization's impact and the role of status competition and international law. In presenting this new narrative for the nineteenth century, it becomes clear that an era long considered uninteresting on Eurocentric grounds is in fact crucial and pivotal in global terms. This work will be of particular interest to students and scholars of the history of international relations.

This edited volume presents a new, grand and global narrative for international relations (IR) history in the pivotal nineteenth century. Typically considered by IR scholars to be a long century of relative peace after 1815, the contributors offer a reconceptualization of IR in this century, arguing that it is temporally bifurcated, with very different patterns of behavior in the first and second halves. A mid-century discontinuity - a "pivot period" - marks the transition phase in Europe and globally when, in the space of a few years, a shift occurred from a comparatively calm, politically disconnected world under loose British free trade hegemony to one of scrambles for territory and keen interest in imperial possessions and conquest. All the book's chapters deal with characterizing patterns of relations in the first half of the century or the second, with two addressing the discontinuity in the middle. In the first half aspects of regional orders are described (in Latin America, East Asia and Europe) alongside crucial developmental processes (missionaries and colonial expansion, the agency of regionally localized actors, of leading elites). In the second half, there is again discussion of regional developments (East Asia, Europe), but now under the onslaught and pressures of the latter half of the century, and spotlighting industrialization's impact and the role of status competition and international law. In presenting this new narrative for the nineteenth century, it becomes clear that an era long considered uninteresting on Eurocentric grounds is in fact crucial and pivotal in global terms. This work will be of particular interest to students and scholars of the history of international relations.

The field of pediatric oncology encompasses four groups of malignancies - acute leukemias, brain tumors, lymphomas and solid tumors. 1'he history, diagnosis and management of children with acute leukemias and lymphomas has been thoroughly examined in several excellent textbooks of pediatric hematology and oncology. Bl"ain tumors have historically been managed by neurosurgeons and radiation therapists. 1'he role of the pediatric oncologist in the management of these patients is evolving. This book was written to provide a thorough historical evaluation of the most frequent solid tumors of children. A detailed examination of the natural history of these tumors is essential to the design and evaluation of therapeutic trials. The highly lethal nature of many of these tumors, the occurrence of some of them at several different primary sites and the rarity of these tumors have made systematic study of them difficult. Conclusions regarding the efficacy of a particular modification of the therapeutic strategy can be strongly influenced by the assumed natural history of the tumor. I have tried to develop as accurateJy as the literature would allow a picture of the natural history of the common malignant solid tumors, knowing that the image would be imperfect. I adopted a convention which was employed in all graphs constructeil from case reports summarized from the literature.