Myelodysplastic syndrome (MDS) is a family of clonal haematopoietic stem cells disorders characterized by dysplasia, ineffective hematopoiesis and susceptibility to transformation to Acute Myeloblastic Leukaemia (AML) that are shown to be strikingly refractory to current therapeutic modalities. The first chapter of this book provides a detailed review of the risk factors, treatment options and prognosis of MDS. Chapter two studies the inflammatory and autoimmune nature of MDS. Chapter three discusses the pathogenesis of 5q-syndrome. Chapter four examines the genetic mutations identified in MDS and their significance. Chapter five reviews different prognostic factors and stratifications of risk in Argentinean patients with MDS. Chapter six discusses epigenetics and epigenetic therapy. Chapter seven introduces mild oral chemotherapy treatments for elderly patients with a higher-risk myelodyspastic syndrome. Chapter eight discusses lenalidomide treatment in lower risk myelodysplastic syndromes. Chapter nine analyzes the old and new-integrating prognostic models and mutational advances with epigenetic and cellular therapies for MDS. The last chapter studies the entropy evaluation of bone marrow biopsies in MDS.

The much anticipated debut collection from Deanna Rodger demonstrates a remarkable ability to craft timeless poems. Spanning 10 years they embody the politics of state and person, the city to the universe. Featuring commissions from St Paul's Cathedral, Buckingham Palace and Guardian News and well known poems such as 'Cog' and 'Being British' and the startlingly abrupt `Nowadays'. I Did It Too is a public admittance, a powerful statement in this time of history...

Five new poems from Deanna Rodger. Each one inspired by one of Kevin Elyot's plays: Coming Clean, Forty Winks, And Then There Were None, Perfect Moment, Twilight Song. To honour the emphasis Elyot placed on style and form, all poems: Must be written from the perspective of an inanimate object. Must be written in a poetic form. Must be on the theme of sex. This work was inspired and developed through the generous support of the Kevin Elyot Award at the University of Bristol Theatre Collection.