This book constitutes the proceedings of the 2010 Joint International Working C- ference of the International Federation for Information Processing Working Groups 8.2 and 8.6. Both working groups are part of IFIP Technical Committee 8, the tech- cal committee addressing the field of Information Systems. IFIP WG 8.2, the Inter- tion of Information Systems and Organizations, was established in 1977. IFIP WG 8.6, Diffusion, Transfer and Implementation of Information Technology, was est- lished in 1994. In accordance with their respective themes, both IFIP WG 8.2 and IFIP WG 8.6 have long had an interest in the human impact of information systems. In December 1998, they held a joint working conference in Helsinki, Finland, on the theme "Inf- mation Systems: Current Issues and Future Challenges." The two working groups' joint interest in and collaboration on research concerning the human side of IS is c- tinued and extended through this joint working conference, held on the campus of Curtin University of Technology, from March 30 to April 1, 2010, in Perth, Western Australia. This conference, "Human Benefit Through the Diffusion of Information Systems Design Science Research," combines the traditional themes of the two working groups with the growing interest within the IS research field in the area of design science research.