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Infection with the human immunodeficiency virus is characterized by
the destruction of the host immune system as also reflected by a
progressive loss of CD4-positive T-cells. This finally results in
the host's incapacity to deal with opportunistic infections and the
immune surveillance of tumors, a clinical status known as the
Acquired Immunodeficiency Syndrome (AIDS). The book AIDS
Pathogenesis provides the reader with a complete overview of the
clinical course of HIV-1 infection. It describes the clinical
aspects of primary infection, the different clinical outcomes of
HIV-1 infection, and strategies for anti-viral treatment. In
addition, more fundamental aspects of HIV-1 infection are reviewed.
These include the biology of the virus and the novel insights in
AIDS pathogenesis. Not only is the significance of an HIV-specific
cellular and humoral immune response discussed, but also the
possible incapacity of the adult human host to deal with T-cell
destruction. Finally, the book discusses the currently used
laboratory markers that allow for monitoring of the clinical course
of infection.
This open access book provides a broad context for the
understanding of current problems of science and of the different
movements aiming to improve the societal impact of science and
research. The author offers insights with regard to ideas, old and
new, about science, and their historical origins in philosophy and
sociology of science, which is of interest to a broad readership.
The book shows that scientifically grounded knowledge is required
and helpful in understanding intellectual and political positions
in various discussions on the grand challenges of our time and how
science makes impact on society. The book reveals why interventions
that look good or even obvious, are often met with resistance and
are hard to realize in practice. Based on a thorough analysis, as
well as personal experiences in aids research, university
administration and as a science observer, the author provides -
while being totally open regarding science's limitations- a
realistic narrative about how research is conducted, and how
reliable 'objective' knowledge is produced. His idea of science,
which draws heavily on American pragmatism, fits in with the global
Open Science movement. It is argued that Open Science is a truly
and historically unique movement in that it translates the analysis
of the problems of science into major institutional actions of
system change in order to improve academic culture and the impact
of science, engaging all actors in the field of science and
academia.
This open access book provides a broad context for the
understanding of current problems of science and of the different
movements aiming to improve the societal impact of science and
research. The author offers insights with regard to ideas, old and
new, about science, and their historical origins in philosophy and
sociology of science, which is of interest to a broad readership.
The book shows that scientifically grounded knowledge is required
and helpful in understanding intellectual and political positions
in various discussions on the grand challenges of our time and how
science makes impact on society. The book reveals why interventions
that look good or even obvious, are often met with resistance and
are hard to realize in practice. Based on a thorough analysis, as
well as personal experiences in aids research, university
administration and as a science observer, the author provides -
while being totally open regarding science's limitations- a
realistic narrative about how research is conducted, and how
reliable 'objective' knowledge is produced. His idea of science,
which draws heavily on American pragmatism, fits in with the global
Open Science movement. It is argued that Open Science is a truly
and historically unique movement in that it translates the analysis
of the problems of science into major institutional actions of
system change in order to improve academic culture and the impact
of science, engaging all actors in the field of science and
academia.
Infection with the human immunodeficiency virus is characterized by
the destruction of the host immune system as also reflected by a
progressive loss of CD4-positive T-cells. This finally results in
the host's incapacity to deal with opportunistic infections and the
immune surveillance of tumors, a clinical status known as the
Acquired Immunodeficiency Syndrome (AIDS). The book AIDS
Pathogenesis provides the reader with a complete overview of the
clinical course of HIV-1 infection. It describes the clinical
aspects of primary infection, the different clinical outcomes of
HIV-1 infection, and strategies for anti-viral treatment. In
addition, more fundamental aspects of HIV-1 infection are reviewed.
These include the biology of the virus and the novel insights in
AIDS pathogenesis. Not only is the significance of an HIV-specific
cellular and humoral immune response discussed, but also the
possible incapacity of the adult human host to deal with T-cell
destruction. Finally, the book discusses the currently used
laboratory markers that allow for monitoring of the clinical course
of infection.
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