An overview of practice and theory in both neural specialties, encouraging a broader therapeutic approach to problems such as movement disorders and intractable pain. The concept of this book is to merge neurological and neurosurgical principles and practice, for improved patient care. This includes a review of the basic neurosciences, especially neurogenetics. Details of the neurological examination and neurodiagnostic studies are oriented to specific clinical factors. Attention is directed to advances in molecular biology in the current research in metabolic disorders affecting the neurological system. There is a comprehensive approach to demyelinating diseases and dementia, as well as practical aspects in the diagnosis and management of neurological disorders caused by trauma, vascular lesions, neoplasms and infection. The goal is to share the expertise of both neural specialties in therapy of problems such as movement disorders and intractable pain. A general need for the above has become apparent, in an era of an aging population and increased incidence of neurological disorders. Frank P. Smith, MD, is Professor of Neurosurgery Emeritus, University of Rochester Medical Center