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The last decade has witnessed the unravelling of remarkable new
insights into the biology of Vibrio cholerae. These include the
discovery of the filamentous phage that encodes cholera toxin, the
existence of two chromosomes in V. cholerae, and the sequencing of
the whole genome of the V. cholerae O1 strain N16961. These
pioneering works have led to an inevitable escalation in the amount
of data generated. This book distills the essence of this mighty
deluge of information, providing a timely review of the genomics
and molecular biology of this important human pathogen. Written by
leading V. cholerae experts, the chapters review the most important
cutting-edge genetic facets of V. cholerae including its genomic
organization, population genetics, molecular epidemiology, and
synchronized regulation of gene expression. Other topics include
the molecular basis for enhanced transmissibility of cholera during
epidemics, survival of the pathogen in the environment, and above
all the evolution
The most feared attribute of the human pathogen "Vibrio
cholerae" is its ability to cause outbreaks that spread like
wildfire, completely overwhelming public health systems and causing
widespread suffering and death. This volume starts with a
description of the contrasting patterns of outbreaks caused by the
classical and El Tor biotypes of "V. cholerae." Subsequent chapters
examine cholera outbreaks in detail, including possible sources of
infection and molecular epidemiology on three different continents,
the emergence of new clones through the bactericidal selection
process of lytic cholera phages, the circulation and transmission
of clones of the pathogen during outbreaks and novel approaches to
modeling cholera outbreaks. A further contribution deals with the
application of the genomic sciences to trace the spread of cholera
epidemics and how this information can be used to control cholera
outbreaks. The book closes with an analysis of the potential use of
killed oral cholera vaccines to stop the spread of cholera
outbreaks.
The most feared attribute of the human pathogen Vibrio cholerae is
its ability to cause outbreaks that spread like wildfire,
completely overwhelming public health systems and causing
widespread suffering and death. This volume starts with a
description of the contrasting patterns of outbreaks caused by the
classical and El Tor biotypes of V. cholerae. Subsequent chapters
examine cholera outbreaks in detail, including possible sources of
infection and molecular epidemiology on three different continents,
the emergence of new clones through the bactericidal selection
process of lytic cholera phages, the circulation and transmission
of clones of the pathogen during outbreaks and novel approaches to
modeling cholera outbreaks. A further contribution deals with the
application of the genomic sciences to trace the spread of cholera
epidemics and how this information can be used to control cholera
outbreaks. The book closes with an analysis of the potential use of
killed oral cholera vaccines to stop the spread of cholera
outbreaks.
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