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The method has also been developed for dissolution of antidiabetic
drugs. Initially the solubility was determined in different
dissolution media. The dissolution study of drugs was performed in
7.8 pH phosphate buffer in which these two drugs shows highest
solubility. The dissolution was performed in pH 2.0 medium. The
dissolution study was performed using Paddle with sinkers at 75
rpm. The amount of drugs were estimated.
The objective of this study was to optimize a periodontal drug
delivery system containing antibacterial drugs having synergistic
activity for the treatment of mixed periodontal infections.
Periodontal pockets provide natural reservoir bathed by gingival
crevicular fluid that is easily accessible for the insertion of a
delivery device. Controlled release delivery of antimicrobials
directly into periodontal pockets has received great interest and
appears to hold a sound promise in periodontal therapy. Both
topical drug delivery and controlled drug release have been termed
as local drug delivery. It does not substitute the local
instrumentation but acts as an adjunct to it. The periodic use of
local drug delivery in minimizing bleeding, stabilizing attachment
levels and thereby reducing probing depth, would allow better
control and management of periodontal disease. Various drugs have
been under investigation for more than 3 decades promising
encouraging results. The rationales of using antibacterial drugs
through local delivery into the periodontal pockets have been
discussed.
The present study carried out pharmaceutical dosage and API. From
above study, it is concluded that testing of solid dosage form and
Active Pharmaceutical ingredient or analysis of solid dosage form
and Active Pharmaceutical ingredient used to well developed
function of body and work properly.By the above study both drugs
are present in good conditions and formed according to
pharmacopoeia. These both of drugs safe can be use to treatment of
disease.
The study demonstrated the possibility of significantly improving
the dissolution performance of MX by simultaneous complexation with
cyclodextrin. The importance of proper selection of the most
suitable counter ion to adequately improve the cyclodextrin -
complexation efficiency has been pointed out. PVP showed a
synergistic effect when used in combination with HP -CD. Phase
solubility experiments demonstrated that the ternary system with
PVP (pH 5.8) exhibited a stability constant 12.9 times greater than
the binary complex. The drug solubility in the presence of 50mM HP
-CD was about 6.23 times higher than that in the binary system.
Results confirmed that the strong increase in the drug solubility
shown by HP -CD ternary system with PVP. Solid state demonstrated
that freeze drying technique was suitable for obtaining solid
homogeneous equimolar MX-HP -CD-PVP complexes. These systems could
be useful for formulating fast-dissolving drug solid dosage form
able to assure rapid onset of analgesic action and improved
bioavailability."
Extended release of solid dispersion of water soluble PHC was
successively prepared by coevaporation with Eudragit RLPO in 1: 5
ratios. The sustainment of drug release was effected by
drug-polymer ratio and method of preparation. The analysis by
spectral techniques (FT-IR, FT-NMR) suggested possibility of
hydrogen bonding. The results of DSC, XRD and SEM studies revealed
the reduction in crystallinity of pure drug in solid dispersions as
compared to their physical mixtures. The results of solubility
studies were in accordance with the in vitro release profile and
the order of sustainment of drug release was found in rank order of
0.1 N HCl (pH 1.2)
Leflunomide is a drug with limited water solubility. It exhibits
four polymorphic forms I, II, III, IV. In the present study, form
II polymorph was formulated using form I. Form II polymorph readily
dissolves in water than does form I. The crystals of form I and II
polymorph were characterized by IR, DSC, XRPD. Comparison of
solubility of form I and form II was done by UV Spectrophotometer.
There was a significant increase in solubility of form II. Aqueous
film-coated tablets of form I and form II were prepared using the
same processing parameters and compared for the rate of
dissolution. Form II tablets showed a significant improvement in
terms of dissolution rate, drug release and solubili
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