Evoking such classics as Elmer Gantry and The Day of the Locust, William Giraldi’s About Face boldly transfers the perennial literary themes of celebrity, ambition, and obsession to twenty-first-century Boston. There we meet Val Face, a charismatic self-help guru who captivates multitudes with his uncanny ability to heal adherents using only the power of his words, the mysterious touch of his hands, and the transcendent beauty of his face. Assigned to write a profile of Val Face during his much-hyped New England tour, thirty-year-old impoverished journalist Seger Jovi pens a brutal hatchet job. But Seger, at once curious and incredulous, is soon sucked into the mystic’s vortex of fame, becoming a devotee himself as he contends with the machinations and absurdities of Face’s many protectors, from beefcake bodyguards to helicoptering handlers to Face’s unwavering spouse, Nimble. At first unwilling to sacrifice his principles to fulfill his own ambition and rise from privation, then touched by Face’s unexpected humanity, Seger oscillates between acting as Face’s cynical foil and becoming his unlikely ally. Just as the exalted guru appears to be reaching the apex of his powers, danger threatens from the periphery in the form of an obsessive stalker who wants Face dead. To curb this stalker before he can do harm, Face’s security team enlists the aid of Jackie Jaworski, an ex-Marine and resourceful Boston detective who moonlights as a novelist of thrillers. And so About Face, building to a denouement that will astonish readers, takes us into the convergence of violence and fame that has come to define so much of American popular culture over the last half-century. With its indelible array of characters, hypnotic pacing, and shocking conclusion—and “a mesmerizing prose style that is downright pyrotechnic in its brilliance” (Andre Dubus III)—About Face is a novel in the grand tradition that dances along the tenuous line between the sacred and the profane.

Triazenes: Synthesis and Chemical Properties.- Mechanisms of the Biological Actions of Triazenes.- Triazenes and Triazene N-Oxides: Antitumour Action in Animal Tumour Systems.- Antimestastatic Action of Triazene Derivatives.- Effects of Triazenes on Immune Responses.- Xenogenization of Experimental Tumors by Triazene Derivatives.- The Metabolism of Antineoplastic Triazenes.- Notes on the Metabolism, Pharmacokinetics and Mode of Action of N-Methyl and N-Ethyl-Triazenes in Relation to Their Pharmacological Activity.- Clinical Use of Triazenes.- Clinical Studies with the p-Carboxyl-Dimethyl-Phenyl-Triazene CB10-277.- Triazenes: Therapeutic Considerations and Perspectives.- Antitumor Imidazotetrazines: Prodrugs Targeted to the Major Groove of DNA.- O6-Alkylguanine-DNA-Alkyltransferase Gene Expression and the Cytotoxicity of Triazenes.- N-Methylmelamines, a Unique Class of Anti-Tumour Agents?.- Experimental Background and Early Clinical Studies with Imidazotetrazine Derivatives.- 'O6-Alkylguanine-DNA-Alkyltransferase: Significance, Methods of Measurement and Some Human Tumor and Normal Tissue Levels' (Contributions of the Workshop).- Summary of Poster-Sessions.- Contributors.

A terrifying literary thriller set on the Alaskan tundra, about the mystery of evil and mankind's losing battle with nature. NOW ON NETFLIX Wolves have come for the children of Keelut. Three children have been taken from this isolated Alaskan village, including the six-year-old boy of Medora and Vernon Slone. Wolf expert Russell Core arrives in Keelut to investigate the killings and learns of the horrifying darkness at the heart of Medora. When her husband returns from a desert war to discover his boy dead and his wife missing, he begins a maniacal pursuit that cuts a bloody swathe across the frozen landscape. As Core attempts to rescue Medora from her husband's vengeance, he comes face to face with an unspeakable secret about the indestructible bonds of family, and the untamed animal in the soul of every human being. An epic woven of both blood and myth, Hold the Dark recalls the extreme climate and tribalism of Daniel Woodrell's Winter's Bone and the primeval violence of James Dickey's Deliverance.

This book examines existing treatments, legislation and research methodology of depression and exposes their limitations, championing psycho-social support as an alternative. Depression, affecting 350 million people according to the World Health Organisation, is almost invariably diagnosed by the criteria of the American Psychiatric Association - a definition which encompasses those with normal emotional responses to stressful life events. Tullio Giraldi discusses recent developments in popular and academic dialogue related to the use of antidepressants and recent increases in depression diagnosis and laments the rise in prescribing antidepressants despite their links to suicide and unfulfilled promises of efficacy and safety. He argues that psychotherapy is a cost effective treatment devoid of drugs' adverse effects. This work presents psycho-social support as an alternative to antidepressants, particularly for less severe cases, and as a more effective strategy for coping with the emotional challenges of today's global reality. Patients, students of medicine and psychology, and professionals of mental health will find this work valuable.

Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.

This book critically examines the development of mindfulness, tracing its development from Buddhist meditation to its variety of popular applications today, including the treatment of mental disorders, wellbeing and improvement of performance. The book begins with a chapter on the meaning of mindfulness, then moves on to chart the spread of Buddhism into the western world and examine the development of Mindfulness Based Cognitive Therapy (MBCT). The second half of the book considers some of the growing concerns related to mindfulness such as the loss of the moral and communitarian values of Buddhism, and the psychologicization and medicalization of existential problems into a capitalist society.

More than 25 years have elapsed since the development of the seminal idea which led to the synthesis of dimethyl triazenes as antitumor agents. The original suggestion of Shealy et ale was to use 4-imidazone-carboxarnide as the carrier of a nitro- gen-containing cytotoxic function. 5-diazoimidazole-4-carbox- amide (diazo-IC) was synthesized and tested in mice as a potential inhibitor of de novo purine biosynthesis. Its lack of antitumor action was attributed to its polarity and to the resulting poor uptake of this hydrophilic chemical. Diazo-IC was then coupled with dimethylamine, yielding 5, (3,3-dimethyl- l-triazeno)imidazole-4-carboxamide) (DTIC) with the intention of obtaining a less polar and more lipophil~c prod rug which might release diazo-IC intracellularly. Preliminary tests showed that DTIC had good antiumor activity in experimental systems. Further tests demonstrated a broad spectrum of action against rodent tumors, and clinical trials indicated activity against human malignancies. Subsequent clinical use of DTIC has demonstrated its usefulness against malignant melanoma, for which it is currently the drug of choice, and its effective- ness in combination chemotherapy in the treatment of other human cancers. Because of its antitumor activity the mechan- ism of action of DTIC has been investigated in some detail. The original rationale for its development, that is, the hydrolysis in vivo to diazo-IC, has been shown not to be in- volved in th-e-mechansims of action. DTIC requires metabolic acti- vation before it exerts its biological effects.

This book critically examines the development of mindfulness, tracing its development from Buddhist meditation to its variety of popular applications today, including the treatment of mental disorders, wellbeing and improvement of performance. The book begins with a chapter on the meaning of mindfulness, then moves on to chart the spread of Buddhism into the western world and examine the development of Mindfulness Based Cognitive Therapy (MBCT). The second half of the book considers some of the growing concerns related to mindfulness such as the loss of the moral and communitarian values of Buddhism, and the psychologicization and medicalization of existential problems into a capitalist society.

The Hero's Body is a memoir of what it means to be a man in modern America. At just forty-seven years old, William Giraldi's father was killed in a horrific motorcycle accident. Writing here with searing honesty about grief, obsession, shame and identity, he looks back on three generations of men from the blue-collar town of Manville, New Jersey, and tells their stories in tandem: the speed-crazed cult of his father's 'superbikes', each Sunday spent racing fate along the winding back roads of Pennsylvania; the trauma of a son's ultimate loss, and William's attempts to rebuild a self in the manliest costume he knew. For a teen consumed by hardcore bodybuilding, pumping iron was so much more than a sport-it was a hallowed lifeline for a bookish tenth-grader, a way to forge himself a spot amongst his family's imperious patriarchs. A work of lasting literary beauty, lauded by the New Yorker for its 'unrelenting, perfectly paced prose', The Hero's Body is a tale of the working-class male, the codes of machismo and the unspoken bond between father and son.

Echoing a narrative line that includes Kurt Vonnegut and Joseph Heller, William Giraldi's Busy Monsters has been hailed as one of the most exciting fiction debuts in years. Penned with a linguistic bravado that explores the diaphanous line between fiction and fact, this "very funny, very inventive debut novel" (The New Yorker) has at last revived the great American picaresque tradition.

This is a reproduction of a book published before 1923. This book may have occasional imperfections such as missing or blurred pages, poor pictures, errant marks, etc. that were either part of the original artifact, or were introduced by the scanning process. We believe this work is culturally important, and despite the imperfections, have elected to bring it back into print as part of our continuing commitment to the preservation of printed works worldwide. We appreciate your understanding of the imperfections in the preservation process, and hope you enjoy this valuable book.

This is a reproduction of a book published before 1923. This book may have occasional imperfections such as missing or blurred pages, poor pictures, errant marks, etc. that were either part of the original artifact, or were introduced by the scanning process. We believe this work is culturally important, and despite the imperfections, have elected to bring it back into print as part of our continuing commitment to the preservation of printed works worldwide. We appreciate your understanding of the imperfections in the preservation process, and hope you enjoy this valuable book. ++++ The below data was compiled from various identification fields in the bibliographic record of this title. This data is provided as an additional tool in helping to ensure edition identification: ++++ Gli Ecatommiti Ovvero Cento Novelle, Volume 3; Nuova Bibliotheca Popolaire. Classe V: Novelle E Romanzi. Raccolta Di Novellieri Italiani; Gli Ecatommiti Ovvero Cento Novelle; Giambattista Cinzio Giraldi Giambattista Cinzio Giraldi Cugini Pomba, 1854 Drama; Shakespeare; Drama / Shakespeare; Literary Criticism / Shakespeare

Giraldi Cinthio's Discorso intorno al comporre dei romanzi, here translated into English for the first time, was one of the most important critical works of the Renaissance. Written as a defense of Ariosto's Orlando Furioso, Giraldi's discourse is an inquiry both into the nature of poetry and into the characteristics of the "heroic" or epic genre, in which some of the world's richest poems fall. Henry L. Snuggs introduces this translation with an incisive interpretation of Giraldi's critical theory. Giraldi was the first, Snuggs states, to make a significant plea in sixteenth-century criticism for the poetry of that (and our) time. The modern heroic poem cannot imitate the ancient in every respect, he held, for the principles of both decorum and verisimilitude required it to reflect the mores of its own age, although this did not mean the creation of a new genre. That which distinguishes Giraldi as a critic perhaps more than anything else, Snuggs concludes, was his recognition of a poetic unity other than that defined by Aristotle.

Originally published in 1977 this book is a collection of photos, recipes and artwork.