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This book comprehensively reviews the association of homocysteine
metabolism with the etiology of various human disorders. The
well-defined chapters embedded the central and peripheral effects
of homocysteine metabolism intricately related with
cardiovascular, neurodegenerative, metabolic, and autoimmune
disorders. Further, it discusses the mechanisms of perturbance of
cellular proteostasis by elevated homocysteine levels and provides
a comprehensive account of pathophysiological consequences and
clinical implications of homocysteine-containing proteins. The book
also reviews association of genetic variants of homocysteine
metabolic genes with type 2 diabetes mellitus and obesity. It also
describes the molecular mechanism of hyperhomocysteinemia in the
negative/feedback regulation of neural stem cell proliferation and
alterations in DNA methylation. Taken together, it summarizes the
mechanisms of hyper homocysteinemia-induced endothelial dysfunction
and physiological functions of hydrogen sulfide as the protective
agent.
This book comprehensively reviews the association of homocysteine
metabolism with the etiology of various human disorders. The
well-defined chapters embedded the central and peripheral effects
of homocysteine metabolism intricately related with cardiovascular,
neurodegenerative, metabolic, and autoimmune disorders. Further, it
discusses the mechanisms of perturbance of cellular proteostasis by
elevated homocysteine levels and provides a comprehensive account
of pathophysiological consequences and clinical implications of
homocysteine-containing proteins. The book also reviews association
of genetic variants of homocysteine metabolic genes with type 2
diabetes mellitus and obesity. It also describes the molecular
mechanism of hyperhomocysteinemia in the negative/feedback
regulation of neural stem cell proliferation and alterations in DNA
methylation. Taken together, it summarizes the mechanisms of hyper
homocysteinemia-induced endothelial dysfunction and physiological
functions of hydrogen sulfide as the protective agent.
Dengue fever (DF) is an emerging mosquito borne viral disease and
important public health problem in low land of Terai region which
is also expanding to hilly region. This study was designed to
estimate sero-prevalence of dengue virus infection in the post
monsoon period (Jun-Dec) of 2010 in Nepalese patients with fever
visiting hospitals of Birganj, Damouli, Biratnagar and Dhading
Besi. Serum samples were collected from 280 patients visiting
hospitals with history of fever & clinically suspected DF. The
sero-prevalence of dengue virus specific IgM was determined by
enzyme linked immunosorbent assay (ELISA) kit (SD, Korea).
Molecular diagnosis based on RT-PCR was also performed for the
confirmatory diagnosis. The IgM capture ELISA has become the most
accepted technique for the diagnosis of dengue in developing
countries like Nepal.
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Hazaribagh (Paperback)
Pranab Chandra Roy Choudhury; Foreword by Radha Govind Prasad
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R1,063
Discovery Miles 10 630
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Out of stock
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