It is the year 1850. Santos Vega, a hard working mayor, is left murdered, hanging on a tree on the eve of All Saints' Day by a sadistic cult leader known as "The Coyote." The Coyote and his evil Witch sister, along with their followers have been killing and enslaving people across the New Mexico territories. With Santos dead, and the madman in control, the cult makes plans for more converts using the dark magic of The Witch to aid their sinister cause during the town's celebration of Dia de los Muertos. Death itself however has plans for this recently deceased mayor. The Lady of Shadows, Santa Muerta, allows Santos to return from the land of the dead with the supernatural powers of the Day of The Dead. He is given forty-eight hours to save his wife, and the people of his village from the dark cult. He returns to the land of the living to discover he is human by day but dies and transforms at moon's first light to become the living dead. His face changes to a decorated skull and his body becomes cold and pale like a corpse. Santos must free his people and destroy The Coyote, The Witch and their followers by the end of All Souls' Day and stop their horrors from spreading. Armed with twin Walker Colts, a heart of vengeance and the power of Dia de los Muertos, the last thing these evil men will see before they are sent to hell is his skull-like face.