" . . . the motto for the therapeutics of the future will have to be de sedibus et causis pharmacorum. " P. EHRLICH, 1909 Exciting events in the basic disciplines of virology, immunology, and pharmacology continue to advance the understanding of the pathogenesis and control of virus diseases. At the same time, the rational development of antiviral agents is attracting, to an increasing extent, the interest of workers in other disciplines. Improvements in technology facilitate the definition of potential target sites for antiviral intervention and unmask new viral and host genes. The outcome is a further steady development of new antiviral agents which approach the "magic bullets" first proposed by PAUL EHRLICH. Remarkable advances in protein synthetic methods that yield polypeptides which inhibit active sites of viral proteins have aided substantially in the basic and clinical study of these antiviral agents. In addition, the extremely rapid progression in recombinant DNA techniques, leading to the synthesis of large quantities of gene products, is also increasing our opportunities at a dashing pace. New information and developing technology facilitate research on the mechanism of action, toxicity, pharmacokinetics, and pharmacodynamics of new agents. The list of clinically effective antiviral agents is expanding and the number of potentially useful compounds is growing rapidly. This book is a combined theoretical text and practical manual which, it is hoped, will be of use to all who have an interest in virus diseases, particularly scientists, physicians and graduate students.

Die im Wasser enthaltenen Spurenelemente haben eine zentrale Bedeutung sowohl fur die Medizin als auch fur die Geologie. Je nach Zusammensetzung dieser Spurenelemente besitzen die Wasser unterschiedliche medizinische Wirkung und geologische Aussagekraft. OEsterreich besitzt eine Vielzahl verschiedener Mineral- und Heilwasser. Eine Gruppe von Experten auf den Gebieten der Medizin, Lebensmitteltechnologie und Geologie hat sie in ihrer Vielfalt erforscht. Die Ergebnisse dieser Forschungstatigkeit geben Auskunft uber die Herkunft des Wassers, seine Bestandteile und deren Eigenschaften. Als einzigartiges Nachschlagewerk fur alle jene, die an der medizinischen Wirkung der einzelnen Heilwasser und an den geologischen Grundlagen der einzelnen Heilwasserprovinzen OEsterreichs interessiert sind, ist dieses Buch unentbehrlich.

Mark Kinson is an ex-marine, a veteran of the Iraq war, an expert in martial arts and, according to his boss, a terrible private investigator. When he makes a serious blunder and is fired he figures his career is over. It is then that he gets the break of a lifetime. With some help from his sister, he lands a job investigating a murder in the Green Mountains of Vermont. Almost immediately upon arriving however, the case begins to take twists and turns that he could never have imagined, including a bizarre treasure hunt that has an outrageous and exciting conclusion. His main concern, however, is finding the identity of the person that shot John Moorehead. He wades through the many clues but they don't seem to add up. Could the killer be the mild mannered house servant? The doctor? Possibly the matronly woman who serves as a maid and cook? Certainly not the victim's own daughter. Or could it be the very one that hired him, the victims wife? Whoever it is, they keep one step ahead of the sleuth until the very end when suddenly all the many clues, or more precisely several specific ones, come together and he makes a stunning realization. Will he finally figure it out? Will You? The clues are all there for him (and the reader) in this old fashioned styled mystery with contemporary and fascinating characters. And with a surprise ending that will grab the reader by the throat it is a must read for murder mystery buffs.