The vaccines most urgently needed are those againstpoverty-related diseases such as tuberculosis, malaria and HIV.However, there is a considerable gap between the development of avaccine and the implementation as a useful measure for diseasecontrol. Major obstacles need to be overcome even after successfulcompletion of the preclinical stage.

This book provides an important link between vaccine developmentand application under the particular conditions in developingcountries.
The editors, S.H.E. Kaufmann and P.H. Lambert - one from the fieldof basic research and the other an expert on the side of appliedvaccinology - have gathered contributions from specialists of bothfields in an attempt to create a source of information that hasthus far not been available.

The Vaccine Book, Second Edition provides comprehensive information on the current and future state of vaccines. It reveals the scientific opportunities and potential impact of vaccines, including economic and ethical challenges, problems encountered when producing vaccines, how clinical vaccine trials are designed, and how to introduce vaccines into widespread use. Although vaccines are now available for many diseases, there are still challenges ahead for major diseases, such as AIDS, tuberculosis, and malaria. This book is designed for students, researchers, public health officials, and all others interested in increasing their understanding of vaccines. It answers common questions regarding the use of vaccines in the context of a rapidly expanding anti-vaccine environment. This new edition is completely updated and revised with new and unique topics, including new vaccines, problems of declining immunization rates, trust in vaccines, the vaccine hesitancy, and the social value of vaccines for the community vs. the individual child's risk.

In this book the authors present current research in the study of frogs. Frog's neuromuscular junction (NMJ) is a classic and favourite object which have played a leading role in developing understanding of the basic mechanisms of synaptic transmission and secretion of neuromediator. The genetic diversity, neural development and ecological implications of frogs are examined throughout the book. Some of the topics the authors discuss in this compilation include poison storage and maturation in serous cutaneous glands of anurans; a mini review of the suppression of anuran metamorphosis by synthetic chemical compounds; mechanisms of suprathreshold excitation of a frog tectal neuron column by discharge of a single moving edge or darkness detector and their relation to a frog escape reactions; behavioral, ecological, and evolutionary aspects of diversity in frog colour patterns; physiological features of blood's system of frogs rana ridibuda pall; and presynaptic voltage-dependent calcium channels at the frog neurmuscular junction.

This is an EXACT reproduction of a book published before 1923. This IS NOT an OCR'd book with strange characters, introduced typographical errors, and jumbled words. This book may have occasional imperfections such as missing or blurred pages, poor pictures, errant marks, etc. that were either part of the original artifact, or were introduced by the scanning process. We believe this work is culturally important, and despite the imperfections, have elected to bring it back into print as part of our continuing commitment to the preservation of printed works worldwide. We appreciate your understanding of the imperfections in the preservation process, and hope you enjoy this valuable book.

This scarce antiquarian book is included in our special Legacy Reprint Series. In the interest of creating a more extensive selection of rare historical book reprints, we have chosen to reproduce this title even though it may possibly have occasional imperfections such as missing and blurred pages, missing text, poor pictures, markings, dark backgrounds and other reproduction issues beyond our control. Because this work is culturally important, we have made it available as a part of our commitment to protecting, preserving and promoting the world's literature.

This scarce antiquarian book is included in our special Legacy Reprint Series. In the interest of creating a more extensive selection of rare historical book reprints, we have chosen to reproduce this title even though it may possibly have occasional imperfections such as missing and blurred pages, missing text, poor pictures, markings, dark backgrounds and other reproduction issues beyond our control. Because this work is culturally important, we have made it available as a part of our commitment to protecting, preserving and promoting the world's literature.

This scarce antiquarian book is included in our special Legacy Reprint Series. In the interest of creating a more extensive selection of rare historical book reprints, we have chosen to reproduce this title even though it may possibly have occasional imperfections such as missing and blurred pages, missing text, poor pictures, markings, dark backgrounds and other reproduction issues beyond our control. Because this work is culturally important, we have made it available as a part of our commitment to protecting, preserving and promoting the world's literature.