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This book is about neuronal networks within the brain. With roughly
100 billion nerve cells the human brain contains about 3.2 million
kilometers of 'wires' to make a million billion of connections
between these nerve cells. Nerve cells exchange electrical and
chemical signals through these connections and the dynamical
patterns of electrical/chemical signals are the basis of all our
thinking, memories, consciousness, and control of our behaviour.
How do these networks develop their specific connectivity, what are
the patterns of electrical activity that serve such a fundamental
role in our cognitive abilities, how can it go wrong in these
networks resulting in different types of brain pathologies, such as
mental retardation, Alzheimer's disease, epilepsy or schizophrenia?
These questions are among the most fundamental ones in neuroscience
and are addressed in this volume. The chapters in this book cover
both state-of-the-art broad reviews and in-depth studies of topics
selected in order to bridge different levels of neurobiological
organization, from the molecular, cellular, neural network to the
cognitive level. An excellent example of such a 'red thread' is
given by the chapters devoted to the visual system, illustrating
the advanced state of understanding of network development,
plasticity and functioning of the visual system. Other chapters
illustrate how scientific advances are driven by technical
developments as shown for multi-electrode recording and life
imaging techniques that enable the study of electrical activity
simultaneously in many nerve cells.
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