Starting in the late 1980s, the CAiSE series of conferences has established a platform for presenting and exchanging results of design-oriented research in - formation systems. In addition to the presentation of new information systems techniques, recent years have seen the rise of empirical validation of such te- niques. There is also increasing attention for industry participation. The 21st CAiSE conference, held in Amsterdam, The Netherlands, during June 8-12, 2009, continued this tradition. The theme of CAiSE 2009 was "Information Systems for Business Innova- on." Due to the widespread use of the Web, businesses innovate their propo- tions to customers and come up with new IT-enabled services. Such innovation requires understanding of business and technology in an integrated way. Mul- disciplinary research areas such as service science, networked enterprises, and social networking are paying attention to IT and business innovation. This t- me wasevidentbothinthe pre-conferenceworkshopsandinthe invitedspeakers of the conference. The ?rst two days consisted of pre-conference workshops on business process modelling, modelling methods, requirements engineering, organizational mod- ling, interoperabilityandcooperation, the knowledgeindustry, ontologies, gov- nance, Web information systems, business-IT alignment, legal aspects, systems of things and domain engineering. The conference proper was combined with a doctoralconsortiumwherePhDstudentscouldpresentanddiscusstheirresearch plans and with an industrial event with presentations and exhibitions. Four invited speakers shed light on the role of ontologies in business, p- cess mining, business networking and IT entrepeneurship. Highlights of the conference included a concert and dinner in the world-famous Concertgebouw building and a reception in the Muziekgebouw aan het IJ in Amsterdam harbor.

This volume constitutes the proceedings of the 12th IFIP WG 8.1 Conference on the Practice of Enterprise Modeling held in November 2019 in Luxembourg, Luxembourg. The conference was created by the International Federation for Information Processing (IFIP) Working Group 8.1 to offer a forum for knowledge transfer and experience sharing between the academic and practitioner communities. The 15 full papers accepted were carefully reviewed and selected from 35 submissions. They are grouped by the following topics: modeling and ontologies; reference architectures and patterns; methods for architectures and models; and enterprise architecture for security, privacy and compliance.