Saint Augustine -- the celebrated theologian who served as Bishop of Hippo from 396 C.E. until his death in 430 C.E. -- is widely regarded as one of the most influential thinkers in the Western world. His autobiography, "Confessions," remains among the most important religious writings in the Christian tradition. In this eye-opening and eminently readable biography, renowned historical scholar James J. O'Donnell picks up where Augustine himself left off to offer a fascinating, in-depth portrait of an unparalleled politician, writer, and churchman in a time of uncertainty and religious turmoil.

Augustine is a triumphant chronicle of an extraordinary life that is certain to surprise and enlighten even those who believed they knew the complex and remarkable man of God.

Drug Discovery and Development, Third Edition presents up-to-date scientific information for maximizing the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace. It explores many scientific advances in new drug discovery and development for areas such as screening technologies, biotechnology approaches, and evaluation of efficacy and safety of drug candidates through preclinical testing. This book also greatly expands the focus on the clinical pharmacology, regulatory, and business aspects of bringing new drugs to the market and offers coverage of essential topics for companies involved in drug development. Historical perspectives and predicted trends are also provided. Features: Highlights emerging scientific fields relevant to drug discovery such as the microbiome, nanotechnology, and cancer immunotherapy; and novel research tools such as CRISPR and DNA-encoded libraries Case study detailing the discovery of the anti-cancer drug, lorlatinib Venture capitalist commentary on trends and best practices in drug discovery and development Comprehensive review of regulations and their impact on drug development, highlighting special populations, orphan drugs, and pharmaceutical compounding Multidiscipline functioning of an Academic Research Enterprise, plus a chapter on Ethical Concerns in Research Contributions by 70+ experts from industry and academia specialists who developed and are practitioners of the science and business

Drug Discovery and Development, Third Edition presents up-to-date scientific information for maximizing the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace. It explores many scientific advances in new drug discovery and development for areas such as screening technologies, biotechnology approaches, and evaluation of efficacy and safety of drug candidates through preclinical testing. This book also greatly expands the focus on the clinical pharmacology, regulatory, and business aspects of bringing new drugs to the market and offers coverage of essential topics for companies involved in drug development. Historical perspectives and predicted trends are also provided. Features: Highlights emerging scientific fields relevant to drug discovery such as the microbiome, nanotechnology, and cancer immunotherapy; and novel research tools such as CRISPR and DNA-encoded libraries Case study detailing the discovery of the anti-cancer drug, lorlatinib Venture capitalist commentary on trends and best practices in drug discovery and development Comprehensive review of regulations and their impact on drug development, highlighting special populations, orphan drugs, and pharmaceutical compounding Multidiscipline functioning of an Academic Research Enterprise, plus a chapter on Ethical Concerns in Research Contributions by 70+ experts from industry and academia specialists who developed and are practitioners of the science and business

The dream Alexander the Great and Julius Caesar shared of uniting Europe, the Medi-terranean, and the Middle East in a single community shuddered and then collapsed in the wars and disasters of the sixth century. Historian and classicist James J. O'Donnell--who last brought readers his masterful, disturbing, and revelatory biography of Saint Augustine--revisits this old story in a fresh way, bringing home its sometimes painful relevance to today's issues.

With unexpected detail and in his hauntingly vivid style, O'Donnell begins at a time of apparent Roman revival and brings readers to the moment of imminent collapse that just preceded the rise of Islam. Illegal migrations of peoples, religious wars, global pandemics, and the temptations of empire: Rome's end foreshadows today's crises and offers hints how to navigate them--if present leaders will heed this story.

The Confessions of Augustine have long both demanded and eluded the sustained and serious attention to detail that a scholarly commentary can provide. The present work, which is in three volumes, seeks to supplement that lack. A revised Latin text of the Confessions in Volume I forms the basis for a detailed line-by-line commentary (Volumes II-III) designed to elucidate the many layers of meaning in the work. Placing the emphasis primarily on exegesis, Professor O'Donnell opens up new lines of interpretation, as well as giving an abundance of fresh detail to some more familiar themes. At the same time, he clears the way for further scholarly work by furnishing the materials for others to draw on and press the task of interpretation further. A particular feature of the commentary is its attention to the influences in the Confessions of other texts of the Greek and Latin traditions - biblical, ecclesiastical, philosophical, and literary; whilst the place of the Confessions in Augustine's own life and in the history of Christian literature is also illuminated with greater precision.

The Confessions of Augustine have long both demanded and eluded the sustained and serious attention to detail that a scholarly commentary can provide. The present work, which is in three volumes, seeks to supplement that lack. A revised Latin text of the Confessions in Volume I forms the basis for a detailed line-by-line commentary (Volumes II-III) designed to elucidate the many layers of meaning in the work. Placing the emphasis primarily on exegesis, Professor O'Donnell opens up new lines of interpretation, as well as giving an abundance of fresh detail to some more familiar themes. At the same time, he clears the way for further scholarly work by furnishing the materials for others to draw on and press the task of interpretation further. A particular feature of the commentary is its attention to the influences in the Confessions of other texts of the Greek and Latin traditions - biblical, ecclesiastical, philosophical, and literary; whilst the place of the Confessions in Augustine's own life and in the history of Christian literature is also illuminated with greater precision.

The Confessions of Augustine have long both demanded and eluded the sustained and serious attention to detail that a scholarly commentary can provide. The present work, which is in three volumes, seeks to supplement that lack. A revised Latin text of the Confessions in Volume I forms the basis for a detailed line-by-line commentary (Volumes II-III) designed to elucidate the many layers of meaning in the work. Placing the emphasis primarily on exegesis, Professor O'Donnell opens up new lines of interpretation, as well as giving an abundance of fresh detail to some more familiar themes. At the same time, he clears the way for further scholarly work by furnishing the materials for others to draw on and press the task of interpretation further. A particular feature of the commentary is its attention to the influences in the Confessions of other texts of the Greek and Latin traditions - biblical, ecclesiastical, philosophical, and literary; whilst the place of the Confessions in Augustine's own life and in the history of Christian literature is also illuminated with greater precision.

The written word has been a central bearer of culture since antiquity. But its position is now being challenged by the powerful media of electronic communication. In this penetrating and witty book James O'Donnell takes a reading on the promise and the threat of electronic technology for our literate future. In Avatars of the Word O'Donnell reinterprets today's communication revolution through a series of refracted comparisons with earlier revolutionary periods: the transition from oral to written culture, from the papyrus scroll to the codex, from copied manuscript to print. His engaging portrayals of these analogous epochal moments suggest that our steps into cyberspace are not as radical as we might think. Observing how technologies of the word have affected the shaping of culture in the past, and how technological transformation has been managed, we regain models that can help us navigate the electronic transformation now underway. Concluding with a focus on the need to rethink the modern university, O'Donnell specifically addresses learning and teaching in the humanities, proposing ways to seek the greatest benefit from electronic technologies while steering clear of their potential pitfalls.