The present project concerns the development of once-daily floating matrix tablets, which after oral administration show prolonged gastric residence and extended release of drug. The asymmetric screening matrix, a D-optimal design, was used for finding out the significant formulation factors. Tablets were obtained by wet granulation of drug with HPMC K100M and various excipients, followed by compression and were evaluated for buoyancy lag time, Q 6h, Q 24h and floating duration, during screening study. The graphical analysis of coefficients was done to find out significant factors. The response surface modeling (RSM) was performed with significant factors obtained from screening study.The D-optimal design was used for RSM and various prediction plots and contour plots were used for RSM. The desirability function was used to combine all the responses for optimization. The Nelder-Mead simplex method was applied for optimization of formulation. The optimized formulation was evaluated for diff. parameters and compared with marketed formulation.Various model dependent and model independent drug release parameters of optimized formulation were comparable to that of marketed formulatio

A novel series of compounds have been synthesized by reacting 2 amino,4 phenyl thiazole and substituted benzaldehyde. The structures of the synthesized compounds were confirmed by IR, 1H-NMR, mass spectroscopy (MS) and their purity were ascertained by TLC and elemental analysis. The biological evaluation of these compounds shown the presence of anti-bacterial and anti-fungal activity in compounds.