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The discovery of Epstein-Barr virus (EBV) by Epstein, Achong, and
Barr, reported in 1964 (Lancet 1:702-703), was stimulated by Denis
Burkitt's rec- nition of a novel African childhood lymphoma and his
postulation that an infectious agent was involved in the tumor's
etiology (Nature194:232-234, 1962). Since then, molecular and
cellular biological and computational technologies have progressed
by leaps and bounds. The advent of recombinant DNA technology
opened the possibilities of genetic research more than most would
have realized. Not only have the molecular tools permitted the
analyses of viral mechanisms, but, importantly, they have formed
the basis for discerning viral presence and, subsequently, viral
involvement in an increasing number of diseases. Though in every
field of science the search for further knowledge is likely to be a
limitless phenomenon, the distinct goal in EBV research, namely, to
gain sufficient insight into the viral-host interaction to be able
to intercept the pathogenic process, is beginning to be realized.
Epstein-Barr virus research has effectively entered the postgenomic
era that began with the sequencing of the first strains, cloned in
the mid to late 1980s.
The discovery of Epstein-Barr virus (EBV) by Epstein, Achong, and
Barr, reported in 1964 (Lancet 1:702-703), was stimulated by Denis
Burkitt's rec- nition of a novel African childhood lymphoma and his
postulation that an infectious agent was involved in the tumor's
etiology (Nature194:232-234, 1962). Since then, molecular and
cellular biological and computational technologies have progressed
by leaps and bounds. The advent of recombinant DNA technology
opened the possibilities of genetic research more than most would
have realized. Not only have the molecular tools permitted the
analyses of viral mechanisms, but, importantly, they have formed
the basis for discerning viral presence and, subsequently, viral
involvement in an increasing number of diseases. Though in every
field of science the search for further knowledge is likely to be a
limitless phenomenon, the distinct goal in EBV research, namely, to
gain sufficient insight into the viral-host interaction to be able
to intercept the pathogenic process, is beginning to be realized.
Epstein-Barr virus research has effectively entered the postgenomic
era that began with the sequencing of the first strains, cloned in
the mid to late 1980s.
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