The Voice of Clinical Reason Harrison's Principles of Internal Medicine is the world's most trusted clinical medicine text-and a superb resource for learning the art and science of clinical reasoning. Recognized by healthcare professionals worldwide as the leading authority on applied pathophysiology and clinical medicine, Harrison's Principles of Internal Medicine provides the informational foundation you need for the best patient care possible. This new edition is fully updated with timely new chapters and essential updates across the spectrum of internal medicine. Harrison's Principles of Internal Medicine stands as the benchmark for authoritative, practical information on patient care and the pathogenesis and clinical management of symptoms and signs and specific diseases. Written and edited by the world's top experts in their respective fields, this landmark guide provides the comprehensive, accurate, and essential coverage of the pathogenesis, diagnosis, and treatment of disease. Harrison's is world-renowned as the most authoritative source for: * Descriptions of disease mechanisms and how the clinician can apply that knowledge for the best patient care and optimal diagnosis and treatment of specific diseases * Clear, concise schemas that facilitate the generation of differential diagnoses to reason efficiently through complex real world clinical cases * The physiologic and epidemiologic basis of signs and symptoms, which are covered through a wealth of unsurpassed expert guidance and linked to the disease-specific chapters that follow * Updated clinical trial results and recommended guidelines * Excellent and extensive visual support, including radiographs, clinical photos, schematics, and high-quality drawings * Coverage of both therapeutic approaches and specific treatment regimens * Practical clinical decision trees and algorithms * Organ-specific sections, with clinically relevant pathophysiology and practical clinical advice on the approach to the patient, strategies towards building a differential diagnosis, outstanding clinical algorithms and diagnostic schema, a wealth of clinical images and diagrams, current clinical guidelines, general and specific approaches to therapy Harrison's remains the most trusted resource in a world influenced by endless sources of medical information. The most timely and comprehensive updates from the world's top experts are featured in the 21st edition: * Current coverage of the diagnosis and treatment of diseases, from COVID to dementia to sepsis to multiple sclerosis to lung cancer * Updated content that reflects new approved therapeutics and new practice-changing guidelines and evidence summaries * More than 1000 clinical, pathological, and radiographic photographs, diagnostic and therapeutic decision trees, and clear schematics and diagrams describing pathophysiologic processes * More than a dozen atlases featuring curated collections of visual aspects of diagnosis and management * Complete, updated curation and synthesis of primary medical literature which incorporates current data from major studies and clinical trials * Clinical reasoning resources and helpful disease/presentation schemas * Clinically relevant coverage of disease mechanics and pathophysiology, and related therapeutic mechanisms

This fully revised and updated new edition provides a comprehensive look at nitrite and nitrate and their effect on human health and disease. The first section describes the biochemical analysis of nitrite and nitrate and its role in human physiology. The book then shifts to sources of human exposure of nitrite and nitrate, including environmental and dietary. Finally, the last section discusses nitric oxide-based therapeutics and how nitrite and nitrate biochemistry can be safely harnessed to improve human health. Each chapter provides a balanced, evidence-based view and heavily cites the most recent published literature. They follow a strict chapter format which includes keywords, key points, a conclusion highlighting major findings, and extensive references. The second edition contains new chapters on nitrite and nitrate in age medicine, nitrite and nitrate as a treatment for hypertension, and nitrite and nitrate in exercise performance. Additionally, the editors have expanded the biochemistry section to include chapters on nitrate reducing oral bacteria, nitrite mediated S-Nitrosation, epigenetics and the regulation of nitric oxide, and nitrite control of mitochondrial function. Nitrate and Nitrite in Human Health and Disease, 2e, will be of interest to health professionals, nutritionists, dieticians, biomedical scientists, and food scientists.

Leading clinical and experimental investigators comprehensively review the chemistry, biochemistry, molecular biology, physiology, and pathophysiology of nitric oxide in the cardiovascular systems. These experts particularly illuminate nitric oxide biology, its cardiovascular pathophysiology, and its role in cardiovascular therapeutics. Topics also included are the development of nitric oxide donors for the treatment of myocardial ischemia and thrombosis, the development of gene therapeutic restoration of endothelial function in atherosclerosis, and the application of nitric oxide biology to investigative arenas in cardiovascular medicine. With its balanced presentation of basic and clinically relevant information, Nitric Oxide and the Cardiovascular System provides a comprehensive, authoritative guide for all those cardiovascular biologists, cardiologists, physiologists, and cardiovascular surgeons engaged in today's clinical or experimental research.

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. The book that serves as the basis for the popular "Harrison's Podclass" podcast series! This outstanding collection of internal medicine Q&A is perfect for prepping for board or shelf exams, getting in multiple "reps" of self directed learning, and increasing your understanding of clinical reasoning. It's packed with 1,000+ high-quality clinical vignettes, with expert, on-point explanations for correct and incorrect answers. Harrison's Principles of Internal Medicine reflects all the specialties of internal medicine, and has been exhaustively revised and updated to reflect hundreds of never-before published Q&A in board-style format. This great resource will bolster your understanding of pathophysiology, epidemiology, differential diagnosis, clinical decision making, and therapeutics. Illustrations, radiographs, and pathology slides are included throughout. Each question is accompanied by a complete answer and explanation, and cross-referenced to Harrison's Principles of Internal Medicine for deeper-dive understanding. 325 full-color photos and illustrations Clinical vignettes and Q&A presented in board-style format Content consistent with board exam blueprint in internal medicine Aligned with Harrison's Principles of Internal Medicine, the global authority in medicine Explanations for correct and incorrect answer choices

Based on the popular review course from Harvard Medical School, The Brigham Intensive Review of Internal Medicine Question & Answer Companion, 2nd Edition, provides more than 450 questions and in-depth answers on all specialties of internal medicine, as well as palliative care, occupational medicine, psychiatry, and geriatric medicine. Ideal for preparing for certification or maintenance of certification, this highly regarded review tool positions you for exam success! Shares the knowledge and expertise of leading authorities from Harvard as well as former chief residents at Brigham and Women's Hospital. Contains 450+ board review style questions with full discursive responses - all extensively revised to reflect current board standards. Features a brand new, full-color design with all-new diagrams and color photos. Provides thoroughly revised information throughout, with many new figures and updated tables. Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

All the authority of the most trusted brand in medical content in a convenient, portable guide Doody's Core Titles for 2022! The Harrison's Manual, derived from most clinically salient content featured in Harrison's Principles of Internal Medicine, 20th Edition, delivers numerous clinical algorithms in one practical, portable resource. The Manual also includes abundant quick reference tables, plus concise text-providing rapid access to bedside information when decisions need to be made quickly. This full color summary guide covers all diseases and conditions commonly seen in inpatient general medicine, so you can be sure to find invaluable content directly to your workflow and practice. The 20th edition has been updated to reflect the latest clinical developments in medicine. The Manual truly makes it easy to find what you need at the point of care. The easy-to-navigate chapters cover symptoms/signs, medical emergencies, specific diseases, and care of the hospitalized patient, with a particular focus on: Etiology and Epidemiology Clinically Relevant Pathophysiology Signs and Symptoms Differential Diagnosis Physical and Laboratory Findings Therapeutics Practice Guidelines, and more

Based on the popular review course from Harvard Medical School, The Brigham Intensive Review of Internal Medicine, 3rd Edition, provides in-depth coverage on all specialties of internal medicine, as well as palliative care, occupational medicine, psychiatry, and geriatric medicine. Ideal for preparing for certification or recertification, this highly regarded review tool keeps you up to date with tremendous changes in the field, incorporating detailed discussions in every chapter, essential learning points, more than 600 review questions, numerous tables and figures, and more. Organizes 100+ chapters into 10 broad sections, with one additional section devoted to board simulation. Each chapter includes a section of multiple-choice questions. Shares the knowledge and expertise of leading authorities from Harvard as well as former chief residents at Brigham and Women's Hospital, making this an excellent exam review tool as well as a general practice resource. Includes three new chapters: Sedation Agitation-Sleep Deprviation; Hepatitis B and C; and Evaluation of the Dyspneic Patient. Features a brand new, full-color design with all-new diagrams and color photos. Provides extensively revised information throughout, including more MOC-focused content. Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

This fully revised and updated new edition provides a comprehensive look at nitrite and nitrate and their effect on human health and disease. The first section describes the biochemical analysis of nitrite and nitrate and its role in human physiology. The book then shifts to sources of human exposure of nitrite and nitrate, including environmental and dietary. Finally, the last section discusses nitric oxide-based therapeutics and how nitrite and nitrate biochemistry can be safely harnessed to improve human health. Each chapter provides a balanced, evidence-based view and heavily cites the most recent published literature. They follow a strict chapter format which includes keywords, key points, a conclusion highlighting major findings, and extensive references. The second edition contains new chapters on nitrite and nitrate in age medicine, nitrite and nitrate as a treatment for hypertension, and nitrite and nitrate in exercise performance. Additionally, the editors have expanded the biochemistry section to include chapters on nitrate reducing oral bacteria, nitrite mediated S-Nitrosation, epigenetics and the regulation of nitric oxide, and nitrite control of mitochondrial function. Nitrate and Nitrite in Human Health and Disease, 2e, will be of interest to health professionals, nutritionists, dieticians, biomedical scientists, and food scientists.

Nitrite and Nitrate in Human Health and Disease delivers a comprehensive review of nitrite and nitrate biology, from basic biochemistry to the complex physiology and metabolism of these two naturally occurring molecules in the human body. Well-organized and well referenced chapters cover the rich history of nitrite and nitrate, sources of exposure, and the physiological effects when consumed through foods containing nitrite and nitrate. The chapters are written by leading experts, all of whom share their research and perspectives in order to help define the context for benefits vs. any potential risks associated with nitrite and nitrate use, either through dietary ingestion or therapeutic dosing. This diverse collection of authors includes vascular biologists, physiologists, physicians, epidemiologists, cancer biologists, registered dieticians, chemists, and public health experts from five countries in both academia and government. Nitrite and Nitrate in Human Health and Disease provides a balanced view of nitric oxide biochemistry, and nitrite and nitrate biochemistry in physiology and in the food sciences.

Big data, genomics, and quantitative approaches to network-based analysis are combining to advance the frontiers of medicine as never before. Network Medicine introduces this rapidly evolving field of medical research, which promises to revolutionize the diagnosis and treatment of human diseases. With contributions from leading experts that highlight the necessity of a team-based approach in network medicine, this definitive volume provides readers with a state-of-the-art synthesis of the progress being made and the challenges that remain. Medical researchers have long sought to identify single molecular defects that cause diseases, with the goal of developing silver-bullet therapies to treat them. But this paradigm overlooks the inherent complexity of human diseases and has often led to treatments that are inadequate or fraught with adverse side effects. Rather than trying to force disease pathogenesis into a reductionist model, network medicine embraces the complexity of multiple influences on disease and relies on many different types of networks: from the cellular-molecular level of protein-protein interactions to correlational studies of gene expression in biological samples. The authors offer a systematic approach to understanding complex diseases while explaining network medicine's unique features, including the application of modern genomics technologies, biostatistics and bioinformatics, and dynamic systems analysis of complex molecular networks in an integrative context. By developing techniques and technologies that comprehensively assess genetic variation, cellular metabolism, and protein function, network medicine is opening up new vistas for uncovering causes and identifying cures of disease.

With authoritative coverage of everything from recent discoveries in the field of vascular biology to recent clinical trials and evidence-based treatment strategies, Vascular Medicine, 3rd Edition, is your go-to resource for improving your patients' cardiovascular health. Part of the Braunwald family of renowned cardiology references, this updated volume integrates a contemporary understanding of vascular biology with a thorough review of clinical vascular diseases, making it an ideal reference for vascular medicine specialists, general cardiologists, interventional cardiologists, vascular surgeons, and interventional radiologists. Incorporates technologic advances in vascular imaging - including ultrasound, MRI, CTA, and catheter-based angiography - along with more than 230 new figures, providing an up-to-date and complete view of the vascular system and vascular diseases. Covers novel antithrombotic therapies for peripheral artery disease and venous thromboemboism, advances in endovascular interventions for aortic aneurysms, and today's best surgical treatments for vascular diseases. Includes seven new chapters: Pathobiology of Aortic Aneurysms; Pathobiology and Assessment of Cardiovascular Fibrosis; Large Vessel Vasculitis; Medium and Small Vessel Vasculitis; Epidemiology and Prognosis of Venous Thromboembolic Disease; Fibromuscular Dysplasia; and Dermatologic Manifestations of Vascular Disease. Discusses methods for aggressive patient management and disease prevention to ensure minimal risk of further cardiovascular problems. Keeps you current with ACC/AHA and ECC guidelines and the best ways to implement them in clinical practice. Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices

A better understanding of the pathophysiology of renal failure coupled with technological advances in dialysis techniques and renal transplantation have greatly improved the prognosis and survival for patients with end-stage renal disease (ESRD). Unfortunately, the advances and success of treatment are limited by a number of extrarenal complications that can cause significant morbidity and mortality. Of these, cardiovascular abnormalities are the most common, with cardiac complications alone accounting for more than 40% of deaths in international registries. The importance of cardiovascular complications has become more apparent in recent years with the increased prevalence of diabetes mellitus and vascular nephropathy and with the general ageing of patients with ESRD. The past decade has witnessed enormous advances in understanding the causes and pathophysiology of cardiovascular disease, and their diagnosis, treatment, and prevention. It is, therefore, of importance for physicians caring for patients with end- stage renal failure to understand the pathogenesis of cardiovascular complications, to become familiar with modern diagnostic tools and techniques, and to recognise and treat these complications. The goal of this text is to provide a comprehensive review of the pathophysiology and clinical manifestations of the principal cardiovascular complications in patients with chronic renal failure. The text is intended to assist nephrologists, cardiologists, and internists who care for these patients. The book includes nineteen chapters and is organised in three parts. The first includes three chapters dealing with the epidemiology of cardiovascular disease in patients with end-sage renal failure. The second comprises eight chapters on the basic pathophysiology and pathobiology of cardiovascular diseases in the setting of end- stage renal failure. The third includes eight chapters focussing on clinical manifestations and diagnosis of cardiovascular disease in patients with end-stage renal failure and their management.

This question-and-answer companion to The Brigham Intensive Review of Internal Medicine, which is based upon the popular review course from Harvard Medical School, is a study guide for the American Board of Internal Medicine certification or maintenance of certification examination, as well as for general practice review by physicians and residents. Editors Ajay K. Singh and Joseph Loscalzo recruited leading authorities from Harvard as well as former chief residents at Brigham and Women's Hospital to contribute to this book. This thorough resource features 500 board review questions and answers on internal medicine specialties including: Infectious Disease, Hematology and Oncology, Rheumatology, Pulmonary and Critical Care Medicine, Endocrinology, Nephrology and Hypertension, Digestive Diseases and Disorders of the Pancreas and Liver, Cardiovascular Disease, Neurology, and General Internal Medicine. As the required content for the American Board of Internal Medicine continues to evolve, studying can prove challenging. The Brigham Intensive Review of Internal Medicine Question and Answer Companion is the ideal guide for preparing for certification or recertification.

Based upon the popular review course from Harvard Medical School, The Brigham Intensive Review of Internal Medicine is a comprehensive study guide for the American Board of Internal Medicine certification or maintenance of certification examination as well as for general practice review by physicians and residents. This authoritative, thorough resource provides in-depth coverage on all specialties of internal medicine, as well as palliative care, occupational medicine, psychiatry, and geriatric medicine. Editors Ajay K. Singh and Joseph Loscalzo recruited leading authorities from Harvard as well as former chief residents at Brigham and Women's Hospital to contribute to this book. Featuring over 600 board review questions, with numerous tables and figures, chapters offer detailed discussions with emphasis on essential learning points. Over 100 chapters are organized into 10 broad sections, with one additional section dedicated to board simulation. As the required content for the American Board of Internal Medicine continues to evolve, studying can prove challenging. The Brigham Intensive Review of Internal Medicine is the ideal study guide for anyone preparing for certification or recertification.

When Maria Velasquez began to hear the thoughts of others, she knew life would never be the same; but the possibility she could be the savior of not only the world, but an entire galaxy had never crossed her mind. Now Maria finds herself on a journey of self-discovery that takes her from the suburbs of Manhattan to a planet buried deep in the subgalaxy. Maria's guide on her journey is Wynn, the descendant of Paladins sent here to protect Earth from the impending danger posed by the evil Czar Caiphas, leader of the Galactic Socialist Regime. Their mission is to watch and wait for an earthling to emerge whom they believe could be the Heir to Master Suuth, an ancient Master of the Paladins secreted to our world to protect him from the Czar. Accessible through a rift in space, a phenomenon of light and gravity known as the Cold Star, the subgalaxy is a realm ruled by the opposing forces of magic and faith. Ripe with political intrigue and a never-ending state of galactic war, the clashing of our two galaxies promises an explosive result. Can Wynn and Maria unlock the secrets of the Master's Heir and defeat Czar Caiphas and his Knights? Cold Star is a fast-paced futuristic Galactic Fantasy certain to transport you through time and space and leave you wanting more.

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. CELEBRATING THE HISTORY OF AMERICA'S LANDMARK INSTITUTIONThe fascinating true story of Brigham and Women's Hospital Founded in 1913, the Peter Bent Brigham Hospital was the first medical institution since John Hopkins to foster clinical clerkships of medical students in the environment of a modern residency program. Forging a partnership with Harvard Medical School, the Brigham would become a major innovator in clinical research, implementing a new educational model that would inspire other hospitals for generations to come. In 1980 the Brigham merged with two other Boston medical institutions boasting their own profoundly important histories, the Boston Hospital for Women and the Robert Breck Brigham Hospital, to become Brigham and Women's Hospital (BWH). This rich and insightful account brings this remarkable story to life: the milestone achievements, medical breakthroughs, and personal dedication that have made BWH a world-class leader in academic medicine. The Teaching Hospital includes: A comprehensive history of BWH, from its continued commitment to medicine, education, and compassionate care to its ongoing leadership in transforming science-driven healthcare today. A compendium of BWH's famous firsts, including the nation's first maternity ward, the first in-vitro fertilization, the first successful human organ transplant, New England's first coronary care unit, and most recently, the first full-face transplant, as well as cutting-edge research in stem cells, systems biology, and bioengineering. A celebration of Brigham's luminaries and landmarks, from pioneers like Dr. Harvey Cushing, the father of modern neurosurgery, Dr. Bernard Lown, Nobel Peace Prize winning cardiologist, and Paul Farmer, co-founder of Partners in Health, to the hospital's milestone breakthroughs in radiology, arthritis, transplant surgery, immunology, women's health, community health, and more. With invaluable contributions from medical historians and doctors, this essential volume provides an in-depth history of the institution. Here is the evolution of BWH in all its dimensions: its reputation as an education and clinical innovator, its role in fostering groundbreaking biomedical research, its ties to the local community as well as to the nation and the world, its financial and administrative growth across the decades, the personalities who have made BWH famous, and the fascinating inner life of the hospital. Filled with stories of profound commitment, critical analysis, and behind-the-scenes details, the book celebrates the Brigham's history in both a medical and cultural context.