In the late 1980s, it became painfully evident to the pharmaceutical industry that the old paradigm of drug discovery, which involved highly segmented drug - sign and development activities, would not produce an acceptable success rate in the future. Therefore, in the early 1990s a paradigm shift occurred in which drug design and development activities became more highly integrated. This new str- egy required medicinal chemists to design drug candidates with structural f- tures that optimized pharmacological (e. g. , high affinity and specificity for the target receptor), pharmaceutical (e. g. , solubility and chemical stability), bioph- maceutical (e. g. , cell membrane permeability), and metabolic/pharmacokinetic (e. g. , metabolic stability, clearance, and protein binding) properties. Successful implementation of this strategy requires a multidisciplinary team effort, incl- ing scientists from drug design (e. g. , medicinal chemists, cell biologists, en- mologists, pharmacologists) and drug development (e. g. , analytical chemists, pharmaceutical scientists, physiologists, and molecular biologists representing the disciplines of pharmaceutics, biopharmaceutics, and pharmacokinetics/drug metabolism). With this new, highly integrated approach to drug design now widely utilized by the pharmaceutical industry, the editors of this book have provided the sci- tific community with case histories to illustrate the nature of the interdisciplinary interactions necessary to successfully implement this new approach to drug d- covery. In the first chapter, Ralph Hirschmann provides a historical perspective of why this paradigm shift in drug discovery has occurred.

A science-backed method to maximize creative potential in any sphere of life

With the prevalence of computer technology and outsourcing, new jobs and fulfilling lives will rely heavily on creativity and innovation. Keith Sawyer draws from his expansive research of the creative journey, exceptional creators, creative abilities, and world-changing innovations to create an accessible, eight-step program to increasing anyone's creative potential. Sawyer reveals the surprising secrets of highly creative people (such as learning to ask better questions when faced with a problem), demonstrates how to come up with better ideas, and explains how to carry those ideas to fruition most effectively.

This science-backed, step-by step method can maximize our creative potential in any sphere of life.Offers a proven method for developing new ideas and creative problem-solving no matter what your profession Includes an eight-step method, 30 practices, and more than 100 techniques that can be launched at any point in a creative journeyPsychologist, jazz pianist, and author Keith Sawyer studied with world-famous creativity expert Mihaly Csikszentmihalyi

Sawyer's book offers a wealth of easy to apply strategies and ideas for anyone who wants to tap into their creative power.

Think of delicious Pumpkin Bread, Chocolate Hazelnut Cake, and Cheddar Herb Scones homemade from scratch. But who has that kind of time? You can cut your kitchen duty considerably by using the secret ingredient: cake mix! In this unique cookbook, author Sarah K. Sawyer shows readers how to bake all of the classics?and some new surprises?using cake mix. Recipes include:

• French Toast Casserole
• Rocky Road Bars
• Potato Pancakes
• Green Tea Cupcakes
• Rhubarb Strawberry Crumble

Complete with chapters for vegetarians, vegans, and those who have food allergies, this is the perfect cookbook for anyone who wants to cut corners but still present a delicious homemade product. No one will ever know that it's only semi-homemade!

The mid-twentieth century has added new dimensions to the roles and missions long performed by the United States Army. In many lands whose peoples speak alien tongues and observe strange customs, the American soldier is now living and working as ally, friend, and counselor. As a representative of the American way of life, as a persuasive advocate of his country's modern equipment and tactical doctrine, as partner in a global system of achieving security for the entire free world, he is called upon to demonstrate a variety of talents---patience, tact, linguistic ability, and superior professional knowledge, among others. In all that he does, he must make a supreme effort to understand people and traditions often vastly different from his own. One of the pioneers in this new type of Army endeavor was the Military Advisory Group to the Republic of Korea, commonly known as KMAG. The men and officers who served in KMAG during the early days came to know all the frustrations and triumphs, the problems and partial solutions, the failures and successes that characterize new ventures. Major Sawyer and Mr. Hermes have vividly recaptured the spirit and actions of the men of both nations whose joint efforts established a remarkable record of achievement. Though this volume describes the Army's experience in Korea only, the lessons it contains have great value to an officer assigned to advisory group duty in any nation. The book will also introduce the general public to the manner in which the United States soldier can and does meet the ever-changing tasks demanded of him by his countrymen. A professional soldier and a professional military historian pooled their talents to prepare this work. MajorSaver, presently attending the Command and General Staff College at Fort Leavenworth, Kansas, wrote his manuscript while on duty with the Office of the Chief of Military History from 1951 to 1955. A combat veteran of both World War II and the Korean War, he received a battlefield commission in France in 1945 and fought in Korea in 1950 with the 25th Infantry Division. He holds the Silver Star, the Bronze Star Medal, and the Purple Heart. Mr. Hermes, also a World War II veteran, is a graduate of Boston University, where he received an M.A. degree in 1942, and is currently completing requirements for a Ph.D. degree in history at Georgetown University. A staff member of the Office of the Chief of Military History since 1949, he is the author of Truce Tent and Fighting Front, a forthcoming volume in the series UNITED STATES ARMY IN THE KOREAN WAR. William H. Harris Brigadier General, U.S.A. Chief of Military History

Combining a broad analysis of political culture with a particular focus on rhetoric and strategy, Jeffrey Sawyer analyzes the role of pamphlets in the political arena in seventeenth-century France. During the years 1614-1617 a series of conflicts occurred in France, resulting from the struggle for domination of Louis XIII's government. In response more than 1200 pamphlets-some printed in as many as eighteen editions-were produced and distributed. These pamphlets constituted the political press of the period, offering the only significant published source of news and commentary. Sawyer examines key aspects of the impact of pamphleteering: the composition of the targeted public and the ways in which pamphlets were designed to affect its various segments, the interaction of pamphlet printing and political action at the court and provincial levels, and the strong connection between pamphlet content and assumptions on the one hand and the evolution of the French state on the other. His analysis provides new and valuable insights into the rhetoric and practice of politics. Sawyer concludes that French political culture was shaped by the efforts of royal ministers to control political communication. The resulting distortions of public discourse facilitated a spectacular growth of royal power and monarchist ideology and influenced the subsequent history of French politics well into the Revolutionary era. This title is part of UC Press's Voices Revived program, which commemorates University of California Press's mission to seek out and cultivate the brightest minds and give them voice, reach, and impact. Drawing on a backlist dating to 1893, Voices Revived makes high-quality, peer-reviewed scholarship accessible once again using print-on-demand technology. This title was originally published in 1990.

Combining a broad analysis of political culture with a particular focus on rhetoric and strategy, Jeffrey Sawyer analyzes the role of pamphlets in the political arena in seventeenth-century France. During the years 1614-1617 a series of conflicts occurred in France, resulting from the struggle for domination of Louis XIII's government. In response more than 1200 pamphlets-some printed in as many as eighteen editions-were produced and distributed. These pamphlets constituted the political press of the period, offering the only significant published source of news and commentary. Sawyer examines key aspects of the impact of pamphleteering: the composition of the targeted public and the ways in which pamphlets were designed to affect its various segments, the interaction of pamphlet printing and political action at the court and provincial levels, and the strong connection between pamphlet content and assumptions on the one hand and the evolution of the French state on the other. His analysis provides new and valuable insights into the rhetoric and practice of politics. Sawyer concludes that French political culture was shaped by the efforts of royal ministers to control political communication. The resulting distortions of public discourse facilitated a spectacular growth of royal power and monarchist ideology and influenced the subsequent history of French politics well into the Revolutionary era. This title is part of UC Press's Voices Revived program, which commemorates University of California Press's mission to seek out and cultivate the brightest minds and give them voice, reach, and impact. Drawing on a backlist dating to 1893, Voices Revived makes high-quality, peer-reviewed scholarship accessible once again using print-on-demand technology. This title was originally published in 1990.

A Compelling Pioneer Story From Bestselling Author Kim Vogel Sawyer
Fed up with the poor quality of life in 1880 New York, Tarsie Raines encourages her friends Joss and Mary Brubacher to move with their two children to Drayton Valley, Kansas, a booming town hailed in the guidebook as the land of opportunity. She offers to help with expenses and to care for Mary and the children as they travel west by wagon train. But when tragedy strikes on the trip across the prairie, Tarsie is thrown into an arrangement with Joss that leaves both of them questioning God and their dreams for the future. As their funds dwindle and nothing goes as planned, will Tarsie and Joss give up and go their separate ways, or will God use their time in Drayton Valley to turn their hearts toward him?

Tender Romance from Bestselling Author Kim Vogel Sawyer
Ostracized by her tribe because of her white father, Lizzie Dawson lives alone in the mountains of Alaska, practicing the ways of her people even as she resides in the small cabin her father built for her mother. She dreams of reconciling with her grandparents to fulfill her mother's dying request, but she has not yet found a way to bridge the gap that separate her from her tribe.
Clay Selby has always wanted to be like his father, a missionary who holds a great love for the native people and has brought many to God. Clay and his stepsister, Vivian, arrive in Alaska to set up a church and school among the Athbascan people. Clay is totally focused on this goal...until he meets a young, independent Indian woman with the most striking blue eyes he's ever seen.
But Lizzie is clearly not part of the tribe, and befriending her might have dire consequences for his mission. Will Clay be forced to choose between his desire to minister to the natives and the quiet nudging of his heart?