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The Sobotta Coloring Book - for understanding and learning anatomy
The Sobotta Coloring Book offers another excellent way to study
anatomy, perfectly suited to all those who are looking for an
alternative to learning from textbooks. Dealing with the most
important subjects in anatomy, the texts and the simple drawings
designed to be colored-in help to understand and revise the most
important aspects of human anatomy. This turns the book into
something special: the pictures show the basic anatomical details
and the accompanying texts explain the most important aspects of
the structures. By actively interacting with the book through
coloring-in, the content becomes deeply ingrained in the memory.
The Sobotta Coloring Book provides: basic anatomical details in
over 100 sections, using pictures and text concise accompanying
texts for each picture, highlighting important details clinical
references, pointing out their practical relevance sketches of
sectional planes and perspectives which help with orientation
English - Latin Nomenclature
1 Introduction 1. 1 Wnts and Development The f amily of Wnt genes
consists of at least 19 members in vertebrates. Wnts ha v e
multiple roles during normal development and aetiology of diseases
(Wodarz and Nusse 1998; Moon et al. 2002, 2004). These genes encode
for glycoproteins that are released in the intercellular space,
acting as intercellular mediators (Moon et al. 1997). By binding to
their special receptors, the Frizzled (Fz) receptors, they are able
to activate at least three different pathways: the canonical, the
non-canonical and the Ca 2+ pathway (Fig. 1 ). The Wnt family has
been subdivided, using functional assays, into at least two
subclasses. In Xenopus , Wnt1, Wnt3a and Wnt8 are able to induce
axis duplication in embryos, whereas Wnt4, Wnt5a and Wnt11 cannot
(Du et al. 1995). Those Wnts that are able to induce axis
duplication are thought to act canonically; those who cannot are
thought to act non-canonically. In the literature, therefore, some
Wnts are called canonical Wnts while others are called n- cano
nical Wnts, suggesting that a special Wnt always activates the same
signalling pathway. It is unlikely that the specificity dictating
cellular responses resides solely in the Wnt ligands because no one
has reported sequence or structural motifs in Wnts that predict
their activities in these cellular and embryonic assays.
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