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Sustained release drug system is any drug or dosage form
modification that prolongs the therapeutic activity of the drug.
Ideally a sustained release oral dosage form is designed to release
rapidly some predetermined fraction of the total dose in to GI
tract. This fraction (loading dose) is an amount of drug, which
will produce the desired pharmacological response as promptly as
possible and the remaining fraction of the total dose (maintenance
dose) is then release at a constant rate. The rate of the drug
absorption from the entire maintenance dose into the body should
equal to the rate of the drug removal from the body by all the
processes over the time for which the desired intensity of
pharmacological response is required. We sincerely hope that this
book will helpful to student as well as industry and academic
professionals involved in pharmaceutical and other related science.
Novel drug delivery systems (NDDS) have recently gained importance
for delivering a variety of therapeutic agents for both local and
systemic administration. Delivery of drugs directly to targeted
sites of action provides several advantages over non-specific
delivery of drugs. Oral colon targeted drug delivery system is one
of that NDDS which directly deliver a drug in to the colon for
local treatment of a variety of colonic diseases as well as
systemic absorption of proteins and peptides. The Metronidazole is
the drug of choice in the treatment of the diseases like
Amoebiasis, Giardiasis, Trichomonosis and Bacterial Vaginosis. The
aim of the present research was to design, development and
optimization of swellable rupturable system taking account of local
action of the Metronidazole drug in the lower gastrointestinal
tract to kill the bacteria in the disease conditions like
Amoebiasis, Giardiasis and Trichomonosis.
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