Inappropriate activation of the Wnt signaling pathway is observed in many human cancers and is sufficient to drive tumor initiation and progression in numerous contexts. Multiple mechanisms, such as overexpression of Wnt ligands, inactivation of the APC and Axin tumor suppressors, and mutation of -catenin, are responsible for pathway activation in tumor cells. The development of potent Wnt pathway antagonists for therapeutic use has been a major effort for investigators in both academia and industry in recent years. This book will provide an overview of the Wnt pathway as a therapeutic target for cancer, and discuss the preclinical development of inhibitors specifically directed to upstream and downstream components of the pathway.

Combinatorial chemistry in conjunction with High Throughput Screening (HTS) is revolutionizing the drug discovery process. Yet, we have much to learn about the integration of these powerful techniques with information from genomics, proteomics, computation and pharmacokinetics before dramatic increases in the drug discovery/development processes can be achieved. The chapters in this book represent the state of the art regarding the integration of combinatorial chemistry and HTS in connection with anti-inflammatory targets. Obviously, there is much work to be done beyond what is described in this text, nevertheless, it should set the stage for creative thinking among scientists of many disciplines for the accomplishment of our ultimate goals in treating inflammatory diseases.

The most precious natural resource on our planet, water has the power to soothe, hydrate, and heal. World-renowned film photographer Michael Kahn invites us into this meditative realm with more than 60 black-and-white images of pristine waters in North America, Italy, and England, capturing the mists, movement, and quiet depths. He collects his images on traditional black-and-white film and produces luminous silver gelatin prints in his darkroom. The warmly toned photographs, printed in tritone, are interspersed with inspirational quotes that reveal the deep spiritual connection we have with water, and its restorative power.

Inappropriate activation of the Wnt signaling pathway is observed in many human cancers and is sufficient to drive tumor initiation and progression in numerous contexts. Multiple mechanisms, such as overexpression of Wnt ligands, inactivation of the APC and Axin tumor suppressors, and mutation of -catenin, are responsible for pathway activation in tumor cells. The development of potent Wnt pathway antagonists for therapeutic use has been a major effort for investigators in both academia and industry in recent years. This book will provide an overview of the Wnt pathway as a therapeutic target for cancer, and discuss the preclinical development of inhibitors specifically directed to upstream and downstream components of the pathway.

This series of books brings together results of an extensive research programme on aspects of the national systems of innovation in the five BRICS countries - Brazil, Russia, India, China, and South Africa. It provides a comprehensive and comparative examination of the challenges and opportunities faced by these dynamic and emerging economies. In discussing the impact of innovation with respect to economic, geopolitical, socio-cultural, institutional, and technological systems, it reveals the possibilities of new development paradigms for equitable and sustainable growth. This volume analyses the financing of science, technology and innovation in the BRICS economies. It highlights the importance of institutional coordination and the influence of implicit policies on the extent to which capital markets may contribute to innovation financing. It stresses the role of state development banks and similar organisations in promoting high-risk and long-run building of innovative capacities with respect to development strategy. Original and detailed data, together with expert analyses on wide-ranging issues, make this book an invaluable resource for researchers and scholars in economics, development studies and political science, in addition to policy-makers and development practitioners interested in the BRICS countries.

Combinatorial chemistry in conjunction with High Throughput Screening (HTS) is revolutionizing the drug discovery process. Yet, we have much to learn about the integration of these powerful techniques with information from genomics, proteomics, computation and pharmacokinetics before dramatic increases in the drug discovery/development processes can be achieved. The chapters in this book represent the state of the art regarding the integration of combinatorial chemistry and HTS in connection with anti-inflammatory targets. Obviously, there is much work to be done beyond what is described in this text, nevertheless, it should set the stage for creative thinking among scientists of many disciplines for the accomplishment of our ultimate goals in treating inflammatory diseases.

"Lithium-Ion Batteries Hazard and Use Assessment "examines the usage of lithium-ion batteries and cells within consumer, industrial and transportation products, and analyzes the potential hazards associated with their prolonged use. This book also surveys the applicable codes and standards for lithium-ion technology.

"Lithium-Ion Batteries Hazard and Use Assessment "is designed for practitioners as a reference guide for lithium-ion batteries and cells. Researchers working in a related field will also find the book valuable.

This series of books brings together results of an extensive research programme on aspects of the national systems of innovation in the five BRICS countries - Brazil, Russia, India, China, and South Africa. It provides a comprehensive and comparative examination of the challenges and opportunities faced by these dynamic and emerging economies. In discussing the impact of innovation with respect to economic, geopolitical, socio-cultural, institutional, and technological systems, it reveals the possibilities of new development paradigms for equitable and sustainable growth. This volume analyses the financing of science, technology and innovation in the BRICS economies. It highlights the importance of institutional coordination and the influence of implicit policies on the extent to which capital markets may contribute to innovation financing. It stresses the role of state development banks and similar organisations in promoting high-risk and long-run building of innovative capacities with respect to development strategy. Original and detailed data, together with expert analyses on wide-ranging issues, make this book an invaluable resource for researchers and scholars in economics, development studies and political science, in addition to policy-makers and development practitioners interested in the BRICS countries.

In over 60 handmade, black-and-white photographs, renowned film photographer Michael Kahn renders Martha's Vineyard beachscapes in exquisite detail. Produced in his darkroom, these masterful, curated images depict the diversity and intense beauty of this enchanting island. Scenes of Edgartown, South Beach, Zack's Cliffs, and other locations are interspersed with inspirational quotes and poetry. The warm, tritone-printed images represent the artist's 22 years of work using a 1950s camera to capture the area's sculpted beaches on traditional film, and producing the images as luminous silver gelatin prints.

This book is about arming you with one simple tool that will enhance your investment decision-making process - the chart. It is not the Holy Grail and even if applied exactly as offered there is no guarantee that you will be successful. But owning a high quality hammer is no guarantee that the user will build a beautiful house. The hammer is a tool and in most cases the user will still need other tools - and knowledge - to build that house. Despite its enormous and still growing popularity, technical market analysis still gets a bad rap. Purveyors of this art have been called tealeaf readers and many similar names, but that has nothing to do with what technical analysis is attempting to do. If we strip away all the fancy indicators and obtuse jargon, what is left are time-tested methods of finding investment opportunities and assessing their risk. There is no fortune telling here; only figuring out what we can do about the market. And what we do is the only part of the markets that we can control. What this book will do is give you the basics needed to look at a chart and get a feel for what the market or individual stock is doing.It covers only the nuts and bolts of chart analysis, barely touching upon the next level concepts and definitely leaving the whiz-bang stuff well alone. It should be stressed that this book will not replace your current methods of stock selection and investment strategies. What it can do, however, is add a new dimension to the analysis to confirm or refute what is already known. Basically, there is no need to give up other methods for selecting stocks although by the end of the book you may be drawn to further learning and eventually discover that charts can, indeed, be the primary, if not sole, investment decision-making tools.

This book is intended to be something software developers can read fairly easily and quickly. A software manager can provide this book to his or her team to quickly improve the team's interviewing skills. When the team's interviewing skills improve, good hiring choices are made, thereby helping the overall success of their department and company.

East Coast Atlantic Beaches features over 80 museum-quality photographs of lush and serene seascape scenes from world-renowned black-and-white photographer Michael Kahn. These warmly toned black-and-white seaside photographs range from Georgia to Maine, showcasing the beauty of the sand and the sea that speaks to so many of us. Michael grew up spending summer vacations on these Atlantic beaches, and his personal connection to the landscape shines through each minute detail. "Ever since I can remember," Michael says, "I have been infatuated with the sea. I swam, sailed, fished, and collected shells and sharks' teeth that had washed up on the sand. I hid in the dunes and marveled at the treasures the water and wind revealed, then covered again." These luminous silver gelatin prints, developed in Michael's darkroom, masterfully capture the majestic beauty of these beaches.

"Nothing stirs my soul more than watching a 100-year-old classic yacht roll over a wave, sails flared, white water crashing off her bow, crew attentive. Watching these beauties race around a course is truly spectacular." -Michael Kahn. Sailboats features over 75 photographs of stunning sailing images from world-renowned black-and-white photographer Michael Kahn. These warmly toned, classic yet dynamic sailing photographs feature regattas in Antigua, France, England, and more. Working in traditional black-and-white film, Michael Kahn produces luminous silver gelatin prints in his darkroom, which allow the majestic elegance of these sailing vessels to radiate from the page. Whether you are a traditional film photographer or an avid sailor or simply love the exquisite beauty of the ocean, you will cherish these fine prints and elegant book.

Updated with a new introduction by the authors, this anniversary edition shows the sibling relationship as a distinctive emotional, passionate, painful, and solacing power that shapes who we are and who we become. The relationships among brothers and sisters are infinitely varied-a sibling can be one's worst enemy or closest companion. Though their love or hate, envy or compassion, and closeness or rivalry are formed in childhood, these bonds last throughout life, creating character and affecting behavior in numerous situations. Strangely, this profound attachment-second only to the parent-child bond-was rarely studied or understood until recently, perhaps because the feelings siblings have about each other are usually both intense and secret.Bank and Kahn chart this unknown territory, offering a theory of the ways in which siblings attach, create each other's identities, and affect the course of each other's lives. Illustrated with poignant portraits of brothers and sisters in childhood, adolescence, and adulthood, this book provides a profound understanding of these complex and enduring relationships, examining the influence of childhood intimacy, parental behavior, family turmoil, birth order, and gender.Based on more than twenty years of research and clinical evidence, "The Sibling Bond" fifteenth anniversary edition brings fresh insight to important clinical and theoretical issues, including attachment theory, the development of the self, and the emergence of sexual identity. While Bank and Kahn demonstrate the implications of their findings for both individual and family therapy, they also give readers a vivid opportunity to recognize and reflect on their own sibling relationships.

This series of books brings together results of an extensive research programme on aspects of the national systems of innovation (NSI) in the five BRICS countries - Brazil, Russia, India, China, and South Africa. It provides a comprehensive and comparative examination of the challenges and opportunities faced by these dynamic and emerging economies. In discussing the impact of innovation with respect to economic, geopolitical, socio-cultural, institutional, and technological systems, it reveals the possibilities of new development paradigms for equitable and sustainable growth. Original and detailed data, together with expert analyses on wide-ranging issues, make this book an invaluable resource for researchers and scholars in economics, development studies and political science, in addition to policymakers and development practitioners interested in the BRICS countries.