This monograph was assembled to honor Professor Norman Bowery and his work on the 30th anniversary of his discovery of the GABAB receptor. In the present volume, leading neuroscientists from academia and industry provide a perspective of current research, both basic and translational, in the discovery of drugs acting at the GABAB receptor. The topics covered provide a comprehensive review of the field and the current state of research in this area. Included are chapters on the chemistry of GABAB agonists and antagonists, on the genetics and molecular composition of the site, its regulation and trafficking, and its role in controlling cellular, autonomic, and behavioral function. There are also chapters describing the potential clinical utility of drugs regulating GABAB activity receptorin the areas of hypertension, gastroesophageal reflux disease, Down syndrome, depression, and substance abuse.

The information contained in this text will be of particular interest to neuroscientists in general and to neuropharmacologists in particular.
Articles written by leading investigators in the fieldInforms and updates on all the latest developments"

Prolog is a programming language, but a rather unusual one. Prolog'' is short for Programming with Logic'', and the link with logic gives Prolog its special character. At the heart of Prolog lies a surprising idea: don't tell the computer what to do. Instead, describe situations of interest, and compute by asking questions. Prolog will logically deduce new facts about the situations and give its deductions back to us as answers. Why learn Prolog? For a start, its say what the problem is, rather than how to solve it'' stance, means that it is a very high level language, good for knowledge rich applications such as artificial intelligence, natural language processing, and the semantic web. So by studying Prolog, you gain insight into how sophisticated tasks can be handled computationally. Moreover, Prolog requires a different mindset. You have to learn to see problems from a new perspective, declaratively rather than procedurally. Acquiring this mindset, and learning to appreciate the links between logic and programming, makes the study of Prolog both challenging and rewarding. Learn Prolog Now is a practical introduction to this fascinating language. Freely available as a web-book since 2002 (see www.learnprolognow.org) Learn Prolog Now has became one of the most popular introductions to the Prolog programming language, an introduction prized for its clarity and down-to-earth approach. It is widely used as a textbook at university departments around the world, and even more widely used for self study. College Publications is proud to present here the first hard-copy version of this online classic. Carefully revised in the light of reader's feedback, and now with answers to all the exercises, here you will find the essential material required to help you learn Prolog now.