Synthesis of Saturated Heterocycles via Metal-Catalyzed Alkene Carboamination or Carboalkoxylation Reactions, by John P. Wolfe Synthesis of Saturated Heterocycles via Metal-Catalyzed Alkene Diamination, Aminoalkoxylation, or Dialkoxylation Reactions, by Sherry R. Chemler Synthesis of Heterocycles via Metal-Catalyzed Wacker-Type Oxidative Cyclization Reactions of Alkoxy- or Amino-Alkenes, by Wanbin Zhang Synthesis of Saturated Heterocycles via Metal-Catalyzed Hydroamination or Hydroalkoxylation Reactions, by Lisa D. Julian Synthesis of Saturated Heterocycles via Metal-Catalyzed Allylic Alkylation Reactions, by Aaron Aponick Synthesis of Heterocycles via Metal-Catalyzed Cascade/Domino Reactions that Generate a C-N or C-O Bond, by Mark Lautens Synthesis of Saturated Heterocycles via Metal-Catalyzed Formal Cycloaddition Reactions that Generate a C-N or C-O Bond, by Jerome Waser

This in-depth chronicle of 110 families in Washington, DC's Opportunity Scholarship Program provides a realistic look at how urban families experience the process of using school choice vouchers and transform from government clients to consumers of education and active citizens.

Don P. Wolf and Mary Zelinski-Wooten provide a comprehensive review of the procedures and techniques used in assisted reproduction, as well as in nuclear transfer for both the treatment of human infertility and the propagation of animals. Combining the details of clinical application with the physiological facts of reproduction, the authors treat subjects such as the in vitro maturation of oocytes, embryo culture, intracytoplasmic sperm injection, and the process of nuclear transfer. Cutting-edge and wide-ranging, Assisted Fertilization and Nuclear Transfer in Mammals offers clinical ARTs practitioners, research scientists, those responsible for animal care, and students not only an informative historical perspective on the development of ARTs, but also updates on several of the more dynamic clinical areas, and a highly practical understanding of their applications.

Drawing on a rich pragmatist tradition, this book offers an account of the different kinds of 'oughts', or varieties of normativity, that we are subject to contends that there is no conflict between normativity and the world as science describes it. The authors argue that normative claims aim to evaluate, to urge us to do or not do something, and to tell us how a state of affairs ought to be. These claims articulate forms of action-guidance that are different in kind from descriptive claims, with a wholly distinct practical and expressive character. This account suggests that there are no normative facts, and so nothing that needs any troublesome shoehorning into a scientific account of the world. This work explains that nevertheless, normative claims are constrained by the world, and answerable to reason and argumentation, in a way that makes them truth-apt and objective.

This book offers readers a collection of 50 short chapter entries on topics in the philosophy of language. Each entry addresses a paradox, a longstanding puzzle, or a major theme that has emerged in the field from the last 150 years, tracing overlap with issues in philosophy of mind, cognitive science, ethics, political philosophy, and literature. Each of the 50 entries is written as a piece that can stand on its own, though useful connections to other entries are mentioned throughout the text. Readers can open the book and start with almost any of the entries, following themes of greatest interest to them. Each entry includes recommendations for further reading on the topic. Philosophy of Language: 50 Puzzles, Paradoxes, and Thought Experiments is useful as a standalone textbook, or can be supplemented by additional readings that instructors choose. The accessible style makes it suitable for introductory level through intermediate undergraduate courses, as well as for independent learners, or even as a reference for more advanced students and researchers. Key Features: Uses a problem-centered approach to philosophy of language (rather than author- or theory-centered) making the text more inviting to first-time students of the subject. Offers stand-alone chapters, allowing students to quickly understand an issue and giving instructors flexibility in assigning readings to match the themes of the course. Provides up-to-date recommended readings at the end of each chapter, or about 500 sources in total, amounting to an extensive review of the literature on each topic.

This book offers readers a collection of 50 short chapter entries on topics in the philosophy of language. Each entry addresses a paradox, a longstanding puzzle, or a major theme that has emerged in the field from the last 150 years, tracing overlap with issues in philosophy of mind, cognitive science, ethics, political philosophy, and literature. Each of the 50 entries is written as a piece that can stand on its own, though useful connections to other entries are mentioned throughout the text. Readers can open the book and start with almost any of the entries, following themes of greatest interest to them. Each entry includes recommendations for further reading on the topic. Philosophy of Language: 50 Puzzles, Paradoxes, and Thought Experiments is useful as a standalone textbook, or can be supplemented by additional readings that instructors choose. The accessible style makes it suitable for introductory level through intermediate undergraduate courses, as well as for independent learners, or even as a reference for more advanced students and researchers. Key Features: Uses a problem-centered approach to philosophy of language (rather than author- or theory-centered) making the text more inviting to first-time students of the subject. Offers stand-alone chapters, allowing students to quickly understand an issue and giving instructors flexibility in assigning readings to match the themes of the course. Provides up-to-date recommended readings at the end of each chapter, or about 500 sources in total, amounting to an extensive review of the literature on each topic.

Teachers already know that a career in education involves continual growth?and this book, copublished with Kappa Delta Pi, presents a model for delivery of a lifetime of preservice and inservice training. You?ll find practical advice on how administrators and teachers can work collaboratively to create and maintain a model of reflection, renewal, and growth that promotes efficacy as a teacher, particularly through reflective practice. And unlike any other book, you?ll follow the entire lifecycle of a teacher, from preservice through retirement, making it an indispensable resource for educators at every phase of their career.

Why do most people never have sex with close relatives? And why do they disapprove of other people doing so? "Incest Avoidance and Incest Taboos" investigates our human inclination to avoid incest and the powerful taboo against incest found in all societies. Both subjects stir strong feelings and vigorous arguments within and beyond academic circles. With great clarity, Wolf lays out the modern assumptions about both, concluding that all previous approaches lack precision and balance on insecure evidence. Researchers he calls "constitutionalists" explain human incest avoidance by biologically-based natural aversion, but fail to explain incest taboos as cultural universals. By contrast, "conventionalists" ignore the evolutionary roots of avoidance and assume that incest avoidant behavior is guided solely by cultural taboos. Both theories are incomplete.
Wolf tests his own theory with three natural experiments: "bint'amm" (cousin) marriage in Morocco, the rarity of marriage within Israeli kibbutz peer groups, and "minor marriages" (in which baby girls were raised by their future mother-in-law to marry an adoptive "brother") in China and Taiwan. These cross-cultural comparisons complete his original and intellectually rich theory of incest, one that marries biology and culture by accounting for both avoidance and taboo.

Drawing on a rich pragmatist tradition, this book offers an account of the different kinds of 'oughts', or varieties of normativity, that we are subject to contends that there is no conflict between normativity and the world as science describes it. The authors argue that normative claims aim to evaluate, to urge us to do or not do something, and to tell us how a state of affairs ought to be. These claims articulate forms of action-guidance that are different in kind from descriptive claims, with a wholly distinct practical and expressive character. This account suggests that there are no normative facts, and so nothing that needs any troublesome shoehorning into a scientific account of the world. This work explains that nevertheless, normative claims are constrained by the world, and answerable to reason and argumentation, in a way that makes them truth-apt and objective.

Is inbreeding harmful? Are human beings and other primates naturally inclined to mate with their closest relatives? Why is incest widely prohibited? Why does the scope of the prohibition vary from society to society? Why does incest occur despite the prohibition? What are the consequences? After one hundred years of intense argument, a broad consensus has emerged on the first two questions, but the debate over the others continues.
That there is a biological basis for the avoidance of inbreeding seems incontrovertible, but just how injurious inbreeding really is for successive generations remains an open question. Nor has there been any conclusion to the debate over Freud's view that the incest taboo is necessary because humans are sexually attracted to their closest relatives--a claim countered by Westermarck's argument for the sexually inhibiting effects of early childhood association.
This book brings together contributions from the fields of genetics, behavioral biology, primatology, biological and social anthropology, philosophy, and psychiatry which reexamine these questions.

Is inbreeding harmful? Are human beings and other primates naturally inclined to mate with their closest relatives? Why is incest widely prohibited? Why does the scope of the prohibition vary from society to society? Why does incest occur despite the prohibition? What are the consequences? After one hundred years of intense argument, a broad consensus has emerged on the first two questions, but the debate over the others continues.
That there is a biological basis for the avoidance of inbreeding seems incontrovertible, but just how injurious inbreeding really is for successive generations remains an open question. Nor has there been any conclusion to the debate over Freud's view that the incest taboo is necessary because humans are sexually attracted to their closest relatives--a claim countered by Westermarck's argument for the sexually inhibiting effects of early childhood association.
This book brings together contributions from the fields of genetics, behavioral biology, primatology, biological and social anthropology, philosophy, and psychiatry which reexamine these questions.

Synthesis of Saturated Heterocycles via Metal-Catalyzed Alkene Carboamination or Carboalkoxylation Reactions, by John P. Wolfe Synthesis of Saturated Heterocycles via Metal-Catalyzed Alkene Diamination, Aminoalkoxylation, or Dialkoxylation Reactions, by Sherry R. Chemler Synthesis of Heterocycles via Metal-Catalyzed Wacker-Type Oxidative Cyclization Reactions of Alkoxy- or Amino-Alkenes, by Wanbin Zhang Synthesis of Saturated Heterocycles via Metal-Catalyzed Hydroamination or Hydroalkoxylation Reactions, by Lisa D. Julian Synthesis of Saturated Heterocycles via Metal-Catalyzed Allylic Alkylation Reactions, by Aaron Aponick Synthesis of Heterocycles via Metal-Catalyzed Cascade/Domino Reactions that Generate a C-N or C-O Bond, by Mark Lautens Synthesis of Saturated Heterocycles via Metal-Catalyzed Formal Cycloaddition Reactions that Generate a C-N or C-O Bond, by Jerome Waser

What are the core concepts of art therapy? What can you learn from a drawing of a bird's nest, a collage or some scribbles? Why become an art therapist and how do you do it? What happens in the therapy room? In the style of a graphic novel, A Graphic Guide to Art Therapy answers these questions and more. Art therapy and its key concepts, theory and practice are introduced through illustrations and text. Beginning with an overview of art therapy as both a practice and a career, it shows the routes to becoming an art therapist and what the role entails. The essential approaches, frameworks, techniques and assessment styles of art therapy are visualised and discussed, making this book the perfect companion on your journey as an art therapist.

The births of more than 100 apparently normal infants at term following pregnancies initiated by in vitro fertilization and embryo transfer testifies to the successful clinical application of insights obtained from studies in reproductive biology over the last 20 years. In women, these studies have included: 1) characterization of the changes in blood hormone profiles throughout ovulatory menstrual cycles; 2) documentation of the hormonal composition of antral fluid in developing and degenerating preovulatory follicles; 3) correlation of these observations with the state of oocyte maturation and the fertilizability of the oocyte; 4) application of pharmacologic agents for perturbing the normal hormone profiles to regulate the number of preovulatory follicles developing and the time of ovulation; and 5) development of non-invasi ve methods for monitoring follicular development. Optimizing methods for maturing and fertilizing eggs, for moni toring normal development in vi tro, and for transferring and achieving implantation of embryos are continuing concerns of physicians and scientists responsible for extant programs. In addition, all serious students of reproductive biology should critically examine every facet of the processes which must concatenate to assure birth of normal infants following pregnancies achieved by these methods. However, the literature which contains the informational substrate is dispersed widely in a plethora of journals not always readily accessible. Bringing the essentials together facilitates both rapid retrieval of data and access to relevant literature.

The use of human in vitro fertilization in the management of infertility is the outgrowth of years of laboratory observations on in vitro sperm-egg interaction. "The editors of this work have themselves contributed significantly to basic knowledge of the mammalian fertilization process. The observations of Don Wolf on sperm penetration, the block to polyspermy and, most recently, sperm hyperactivation in the monkey and human, Gregory Kopf's elucidation of the mechanisms of sperm activation during penetration and the reciprocal dialogue between sperm and egg, and Barry Bavister's definition of culture conditions and requirements necessary for in vitro oocyte maturation, fertilization and development in model mammalian systems including nonhuman primates have contributed greatly to our understanding of the mammalian fertilization process. Wolf, Kopf and Gerrity have enjoyed substantial interaction with clinicians in Departments of Obstetrics and Gynecology and have been directly involved with successful IVF programs. Both Wolf and Kopf have served as research scientists in the Division of Reproductive Biology at the University of Pennsylvania, which, for more than 22 years, has fostered co-mingling of clinically oriented and basic science faculty. It is through such interaction, which clearly exists at many institutions including the University of Wisconsin, that the process of technology transfer is best served. Without an exquisitely coordinated laboratory, there can be no consistent success in human in vitro fertilization. Quality control is pivotal, but close collaboration between the laboratory and the clinic is also essential as information is shared and correlated.

It is a genuine honor and a privilege of distinction to provide the foreword for the proceedings that follow. This marvelous symposium reflects the unique qualities of its two principal sponsors. Whenever the Oregon Regional Primate Research Center is involved in matters of science, we see a consistent record of exceptional quality in both the work is unequaled and the people who do it. Likewise, Serono Symposia, USA in assuring a world-class speakers' forum, utterly without taint of commercial influence. The proceedings published herein are a remarkable testimony, not only to the contributors, but to Drs. Brenner, Wolf, Stouffer, and Burnett, who have shepherded its conception, presentation, and publication. Readers will notice immediately one of the universal strengths of this total composition; that is, the diversity of investigational interests among attendees. Presentations on the core topic of primate in vitro fertilization and embryo transfer were joined by specialist presentations in related areas, including human-assisted reproductive technologies, reproductive physiology of the great apes, sperm biology, implantation mechanisms, cryobiology, coculture systems for embryogenesis, micromanipulation technologies, and genetic diagnosis of heritable diseases in the pre embryo. Even though pro-fertility issues understandably dominated this forum, there was significant attention given to fertility-control research, especially the role of primates in this endeavor (more on this subject below)."

Don P. Wolf and Mary Zelinski-Wooten provide a comprehensive review of the procedures and techniques used in assisted reproduction, as well as in nuclear transfer for both the treatment of human infertility and the propagation of animals. Combining the details of clinical application with the physiological facts of reproduction, the authors treat subjects such as the in vitro maturation of oocytes, embryo culture, intracytoplasmic sperm injection, and the process of nuclear transfer. Cutting-edge and wide-ranging, Assisted Fertilization and Nuclear Transfer in Mammals offers clinical ARTs practitioners, research scientists, those responsible for animal care, and students not only an informative historical perspective on the development of ARTs, but also updates on several of the more dynamic clinical areas, and a highly practical understanding of their applications.

Typically, we make sense of our experiences and interactions in a way that is guided by emotion and that takes the form of a narrative or a story. Using narratives, we can tell others about our expeirence, share common meanings, imagine possibilities, and co-construct new meanings. It is thus a momentous development when, at around age three, a child acquires the capacity to construct narratives. The book reports the work of a 20-year collaboration between 36 psychologists who have created and investigated a new tool to elicit and analyze children's narratives. This tool is the MacArthur Story Stem Battery, a systematic collection of story beginnings that are referred to as 'stems.' These stems are designed to elicit information from children about their representational worlds. This method is particularly exciting because using it allows developmental psychologists to gain information directly from children about their emotional states and what they are able to understand, and in turn, to use this information to explore significant emotional differences among children.

Drop a pebble in a pond and the results are quite predictable: circular waves flow from the point of impact. Hit a point on a crystalline solid, however, and the expanding waves are highly non-spherical: the elasticity of a crystal is anisotropic. This book provides a fresh look at the vibrational properties of crystalline solids, elucidated by new imaging techniques. From the megahertz vibrations of ultrasound to the near-terahertz vibrations associated with heat, the underlying elastic anisotropy of the crystal asserts itself. Phonons are elementary vibrations that affect many properties of solids - thermal, electrical and magnetic. This text covers the basic theory and experimental observations of phonon propagation in solids. Phonon imaging techniques provide physical insights into such topics as phonon focusing, lattice dynamics and ultrasound propagation. Scattering of phonons from interfaces, superlattices, defects and electrons are treated in detail. The book includes many striking and original illustrations.

Drop a pebble in a pond and the results are predictable: circular waves flow from the point of impact. Hit a point on a crystalline solid, however, and the expanding waves are highly nonspherical; the elasticity of a crystal is anisotropic. This book provides a fresh look at the vibrational properties of crystalline solids, elucidated by new imaging techniques. From the megahertz vibrations of ultrasound to the near-terahertz vibrations associated with heat, the underlying elastic anisotropy of the crystal asserts itself. Phonons are elementary vibrations that affect many properties of solids--thermal, electrical, and magnetic. This text covers the basic theory and experimental observations of phonon propagation in solids. Phonon imaging techniques provide physical insights into such topics as phonon focusing, lattice dynamics, and ultrasound propagation. Scattering of phonons from interfaces, superlattices, defects, and electrons are treated in detail. The book includes many striking and original illustrations.

In 1891, the anthropologist Edward Westermarck proposed that early childhood association inhibits sexual attraction and that this aversion was manifested in custom and law as the basis of the universal incest taboo. Then, in 1910, in the essays later published as Totem and Taboo, Sigmund Freud challenged the "Westermarck hypothesis" on the ground that "the earliest sexual excitations of youthful human beings are invariably of an incestuous character." The incest taboo only existed, Freud argued, because of this natural propensity.
Freud's challenge carried the day and became the standard view throughout the social and biological sciences. Consequently, the question was: why do all societies repress this natural inclination? Biologists argued that the incest taboo protected us from dangers of inbreeding; sociologists argued that it was necessary to prevent sexual rivalry that would destroy the family; and anthropologists saw the real purpose of the taboo as forcing families to exchange women in marriage.
The book uses a wide range of research - from studies of nonhuman primates to reports of incestuous child abuse - from African divorce practices to animal behavior - to demonstrate that Westermarck was right and Freud wrong. It shows that there is a critical period in human development - approximately the first thirty months of life - during which association permanently inhibits sexual attraction. It concludes that the incest taboo is unnecessary and cannot be explained in functional terms, and that encouraging early association between father and daughter is probably the best way of preventing sexual abuse.

This book reflects debates and results which have developed since the introduction of an international system of classifications in epileptology. The creation of such a system was initiated, in the sixties, mainly for practical reasons: growing international exchange had revealed that divergence of terminology in epilepsy had become important enough to prove a serious obstacle to sensible discussions. The Bethel-Cleveland symposia, which was at the origin of this book, aim to bring the excellence of advanced inter-disciplinary and controversial workshops to a larger public. The book concentrates on a selection of topics where progress has been made, where controversies are open or where discussion needs to be stimulated.