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The present investigation is concerned with synthesis of new 2 and
6 - substituted 4H-chromen-4-One derivatives with the objectives of
discovering novel and potent anti-inflammatory agents and
anti-oxidants. The results of anti-inflammatory activity were
revealed that the compound has indole 2 substitution with
4-nitrophenyl amino methyl (at 6th position) on 4H- chromen-4-one
having more anti-inflammatory activity as compared to other
substituent's. While, indole 2 substituted 4-methoxy phenyl amino
methyl (at 6th position) 4H-chromen-4-one showed outperformed
anti-oxidant activity in different anti-oxidant model as compared
to other substituent's. The all newly synthesized compounds
displayed moderate to potent anti-inflammatory and anti-oxidant
activity and has therapeutic potential in combating this
devastating inflammatory and oxidative condition of the body, might
be deserve promising substances for further in vivo evaluation as
anti-inflammatory and anti-oxidant properties. However the
anti-inflammatory activity is not related to antioxidant potential.
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