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Showing 1 - 2 of 2 matches in All Departments
Cutting-edge researchers describe their efforts to design,
synthesize, and evaluate the biological activities of
farensyltransferase inhibitors (FTIs); geranylgeranyltransferase
inhibitors (GGTIs) are also discussed as potential anticancer
drugs. The authors survey in detail such inhibitors as CAAX box
peptidomimetics, FPP mimics, and bisubstrate transition state
analogs, and critically review their uses in combination with
radiation and other cytotoxic agents, such as gemcitabine,
cisplatin, and taxanes. Illuminating and richly detailed,
Farnesyltransferase Inhibitors in Cancer Therapy constitutes
today's standard reference for the pathbreaking use of FTIs and
GGTIs in anticancer therapy and offers basic and clinical
investigators a comprehensive treatment of the scientific and
medical aspects of farnesyltransferase inhibitors.
Cutting-edge researchers describe their efforts to design,
synthesize, and evaluate the biological activities of
farensyltransferase inhibitors (FTIs); geranylgeranyltransferase
inhibitors (GGTIs) are also discussed as potential anticancer
drugs. The authors survey in detail such inhibitors as CAAX box
peptidomimetics, FPP mimics, and bisubstrate transition state
analogs, and critically review their uses in combination with
radiation and other cytotoxic agents, such as gemcitabine,
cisplatin, and taxanes. Illuminating and richly detailed,
Farnesyltransferase Inhibitors in Cancer Therapy constitutes
today's standard reference for the pathbreaking use of FTIs and
GGTIs in anticancer therapy and offers basic and clinical
investigators a comprehensive treatment of the scientific and
medical aspects of farnesyltransferase inhibitors.
|
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