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The last decade has witnessed the unravelling of remarkable new
insights into the biology of Vibrio cholerae. These include the
discovery of the filamentous phage that encodes cholera toxin, the
existence of two chromosomes in V. cholerae, and the sequencing of
the whole genome of the V. cholerae O1 strain N16961. These
pioneering works have led to an inevitable escalation in the amount
of data generated. This book distills the essence of this mighty
deluge of information, providing a timely review of the genomics
and molecular biology of this important human pathogen. Written by
leading V. cholerae experts, the chapters review the most important
cutting-edge genetic facets of V. cholerae including its genomic
organization, population genetics, molecular epidemiology, and
synchronized regulation of gene expression. Other topics include
the molecular basis for enhanced transmissibility of cholera during
epidemics, survival of the pathogen in the environment, and above
all the evolution
Food- and waterborne pathogens continue to be a major cause of
mortality in developing countries and cause significant morbidity
in developed nations. Important pathogens include species or
strains of Salmonella, Vibrio, Shigella, Escherichia coli,
Yersinia, Staphylococcus and Campylobacter. Understanding the
molecular basis of pathogenesis, its evolution and spread is
critical to the development of new strategies for disease
prevention and control. The application of genomic and other omics
technologies in recent years has led to a deluge of information in
this area, making it difficult for the busy researcher to keep
abreast of developments. This timely book aims to capture the
essence of the latest developments to provide a timely overview of
the field.
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