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King of Strong Style - 1980-2014 (Hardcover): Shinsuke Nakamura King of Strong Style - 1980-2014 (Hardcover)
Shinsuke Nakamura; Translated by Jocelyne Allen
R490 R324 Discovery Miles 3 240 Save R166 (34%) Ships in 10 - 15 working days

The life of the internationally famous professional wrestler Shinsuke Nakamura, from his childhood to the International Wrestling Grand Prix championship, and beyond! Before he became a star of American professional wrestling, Shinsuke Nakamura was Japan's "King of Strong Style." Follow his life and career from the amateur grappling ranks to the Nippon Budokon, thrill to his matches against such legends as Kurt Angle and Brock Lesnar, his reign as the youngest New Japan Pro-Wrestling Heavyweight Champion, and his success as a mixed martial artist.

Progranulin and Central Nervous System Disorders (Hardcover, 1st ed. 2019): Hideaki Hara, Masato Hosokawa, Shinsuke Nakamura,... Progranulin and Central Nervous System Disorders (Hardcover, 1st ed. 2019)
Hideaki Hara, Masato Hosokawa, Shinsuke Nakamura, Takayoshi Shimohata, Masugi Nishihara
R3,744 R3,231 Discovery Miles 32 310 Save R513 (14%) Ships in 10 - 15 working days

This book presents the latest knowledge on the roles of progranulin (PGRN) in normal physiology and pathology and explores the emerging significance of PGRN as a therapeutic target and biomarker in various CNS disorders, including frontotemporal lobe degeneration and other neurodegenerative diseases. Following initial recognition of the importance of PGRN in sexual differentiation of the developing brain and adult neurogenesis, it was subsequently discovered that PGRN acts as a chaperone of lysosomal enzymes and plays a crucial role in maintaining cellular protein homeostasis. It has also been found that sex steroids modulate the expression of PGRN and its trophic effects in the developing CNS and that PGRN directly or indirectly influences neural stem and progenitor cells. Against this background, deeper understanding of the molecular and functional properties of PGRN would provide fresh impetus for the development of mechanism-based therapeutic approaches for multiple disorders. Medications targeting the recovery of lysosomal function appear to hold particular promise in patients with neurodegenerative diseases resulting from PGRN insufficiency. In examining multiple aspects of this fascinating field, the book will be of high value for researchers and graduate students.

Progranulin and Central Nervous System Disorders (Paperback, 1st ed. 2019): Hideaki Hara, Masato Hosokawa, Shinsuke Nakamura,... Progranulin and Central Nervous System Disorders (Paperback, 1st ed. 2019)
Hideaki Hara, Masato Hosokawa, Shinsuke Nakamura, Takayoshi Shimohata, Masugi Nishihara
R2,928 Discovery Miles 29 280 Ships in 7 - 11 working days

This book presents the latest knowledge on the roles of progranulin (PGRN) in normal physiology and pathology and explores the emerging significance of PGRN as a therapeutic target and biomarker in various CNS disorders, including frontotemporal lobe degeneration and other neurodegenerative diseases. Following initial recognition of the importance of PGRN in sexual differentiation of the developing brain and adult neurogenesis, it was subsequently discovered that PGRN acts as a chaperone of lysosomal enzymes and plays a crucial role in maintaining cellular protein homeostasis. It has also been found that sex steroids modulate the expression of PGRN and its trophic effects in the developing CNS and that PGRN directly or indirectly influences neural stem and progenitor cells. Against this background, deeper understanding of the molecular and functional properties of PGRN would provide fresh impetus for the development of mechanism-based therapeutic approaches for multiple disorders. Medications targeting the recovery of lysosomal function appear to hold particular promise in patients with neurodegenerative diseases resulting from PGRN insufficiency. In examining multiple aspects of this fascinating field, the book will be of high value for researchers and graduate students.

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