eWork and eBusiness in Architecture, Engineering and Construction 2021 collects the papers presented at the 13th European Conference on Product and Process Modelling (ECPPM 2021, Moscow, 5-7 May 2021). The contributions cover a wide spectrum of thematic areas that hold great promise towards the advancement of research and technological development targeted at the digitalization of the AEC/FM (Architecture, Engineering, Construction and Facilities Management) domains. High quality contributions are devoted to critically important problems that arise, including: Information and Knowledge Management Semantic Web and Linked Data Communication and Collaboration Technologies Software Interoperability BIM Servers and Product Lifecycle Management Systems Digital Twins and Cyber-Physical Systems Sensors and Internet of Things Big Data Artificial and Augmented Intelligence in AEC Construction Management 5D/nD Modelling and Planning Building Performance Simulation Contract, Cost and Risk Management Safety and Quality Sustainable Buildings and Urban Environments Smart Buildings and Cities BIM Standardization, Implementation and Adoption Regulatory and Legal Aspects BIM Education and Training Industrialized Production, Smart Products and Services Over the past quarter century, the biennial ECPPM conference series, as the oldest BIM conference, has provided researchers and practitioners with a unique platform to present and discuss the latest developments regarding emerging BIM technologies and complementary issues for their adoption in the AEC/FM industry.