The Auditory System at the Cocktail Party is a rather whimsical title that points to the very serious challenge faced by listeners in most everyday environments: how to hear out sounds of interest amid a cacophony of competing sounds. The volume presents the mechanisms for bottom-up object formation and top-down object selection that the auditory system employs to meet that challenge. Ear and Brain Mechanisms for Parsing the Auditory Scene by John C. Middlebrooks and Jonathan Z. Simon Auditory Object Formation and Selection by Barbara Shinn-Cunningham, Virginia Best, and Adrian K. C. Lee Energetic Masking and Masking Release by John F. Culling and Michael A. Stone Informational Masking in Speech Recognition by Gerald Kidd, Jr. and H. Steven Colburn Modeling the Cocktail Party Problem by Mounya Elhilali Spatial Stream Segregation by John C. Middlebrooks Human Auditory Neuroscience and the Cocktail Party Problem by Jonathan Z. Simon Infants and Children at the Cocktail Party by Lynne Werner Older Adults at the Cocktail Party by M. Kathleen Pichora-Fuller, Claude Alain, and Bruce A. Schneider Hearing with Cochlear Implants and Hearing Aids in Complex Auditory Scenes by Ruth Y. Litovsky, Matthew J. Goupell, Sara M. Misurelli, and Alan Kan About the Editors: John C. Middlebrooks is a Professor in the Department of Otolaryngology at the University of California, Irvine, with affiliate appointments in the Department of Neurobiology and Behavior, the Department of Cognitive Sciences, and the Department of Biomedical Engineering. Jonathan Z. Simon is a Professor at the University of Maryland, College Park, with joint appointments in the Department of Electrical and Computer Engineering, the Department of Biology, and the Institute for Systems Research. Arthur N. Popper is Professor Emeritus and Research Professor in the Department of Biology at the University of Maryland, College Park. Richard R. Fay is Distinguished Research Professor of Psychology at Loyola University, Chicago. About the Series: The Springer Handbook of Auditory Research presents a series of synthetic reviews of fundamental topics dealing with auditory systems. Each volume is independent and authoritative; taken as a set, this series is the definitive resource in the field.

Although the importance of steric fit for receptor-effector 1 interactions was recognized since Emil Fischer proposed his "lock and key" theory, the whole area of steric properties is still in a very 2-4 early stage of development. We have a fairly good idea about el- tronic and hydrophobic parameters, but it is not easy to describe ste- ric shapes of molecules without a large number of data. There are se- veral cases of good QSAR's developed for rather large series of mole- 5 cules without steric parameters - for example see papers by Hansch , 6 or Franke , but the state of steric parameters is nevertheless one of the most important drawbacks, especially concerning the ability of en- compassing, within a single QSAR, molecules of different shapes and stereoisomers. From today's steric parameters, one may mention the 7 Taft parameters E ' which gave good results in organic chemistry, the S 8 10 ra th er cum b ersome way 0 f measurIng * s h ape d'ff I ere h ces 0 f Amoore - and , 11 12 AllInger ,and the L, B -B parameters of Verloop 1 4 The work described here consists of two types of approaches to the steric fit problem. The first approach consists of developing new parameters to describe different characteristics of the molecular shape (i. e. , branching, bulkiness); this is done by means of topological in- dices.

The Auditory System at the Cocktail Party is a rather whimsical title that points to the very serious challenge faced by listeners in most everyday environments: how to hear out sounds of interest amid a cacophony of competing sounds. The volume presents the mechanisms for bottom-up object formation and top-down object selection that the auditory system employs to meet that challenge. Ear and Brain Mechanisms for Parsing the Auditory Scene by John C. Middlebrooks and Jonathan Z. Simon Auditory Object Formation and Selection by Barbara Shinn-Cunningham, Virginia Best, and Adrian K. C. Lee Energetic Masking and Masking Release by John F. Culling and Michael A. Stone Informational Masking in Speech Recognition by Gerald Kidd, Jr. and H. Steven Colburn Modeling the Cocktail Party Problem by Mounya Elhilali Spatial Stream Segregation by John C. Middlebrooks Human Auditory Neuroscience and the Cocktail Party Problem by Jonathan Z. Simon Infants and Children at the Cocktail Party by Lynne Werner Older Adults at the Cocktail Party by M. Kathleen Pichora-Fuller, Claude Alain, and Bruce A. Schneider Hearing with Cochlear Implants and Hearing Aids in Complex Auditory Scenes by Ruth Y. Litovsky, Matthew J. Goupell, Sara M. Misurelli, and Alan Kan About the Editors: John C. Middlebrooks is a Professor in the Department of Otolaryngology at the University of California, Irvine, with affiliate appointments in the Department of Neurobiology and Behavior, the Department of Cognitive Sciences, and the Department of Biomedical Engineering. Jonathan Z. Simon is a Professor at the University of Maryland, College Park, with joint appointments in the Department of Electrical and Computer Engineering, the Department of Biology, and the Institute for Systems Research. Arthur N. Popper is Professor Emeritus and Research Professor in the Department of Biology at the University of Maryland, College Park. Richard R. Fay is Distinguished Research Professor of Psychology at Loyola University, Chicago. About the Series: The Springer Handbook of Auditory Research presents a series of synthetic reviews of fundamental topics dealing with auditory systems. Each volume is independent and authoritative; taken as a set, this series is the definitive resource in the field.