This work discusses the theoretical abilities of three commonly
used classifier learning methods and optimization techniques to
cope with characteristics of real-world classification problems,
more specifically varying misclassification costs, imbalanced data
sets and varying degrees of hardness of class boundaries. From
these discussions a universally applicable optimization framework
is derived that successfully corrects the error-based inductive
bias of classifier learning methods on image data within the domain
of medical diagnosis. The framework was designed considering
several points for improvement of common optimization techniques,
such as the modification of the optimization procedure for
inducer-specific parameters, the modification of input data by an
arcing algorithm, and the combination of classifiers according to
locally-adaptive, cost-sensitive voting schemes. The framework is
designed to make the learning process cost-sensitive and to enforce
more balanced misclassification costs between classes. Results on
the evaluated domain are promising, while further improvements can
be expected after some modifications to the framework.
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