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Books > Computing & IT > General theory of computing
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Computational Systems Biology with Constraints (Paperback)
Loot Price: R2,042
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Computational Systems Biology with Constraints (Paperback)
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Recently, stochastic process algebras have been used for modeling
biological systems, as they provide a simple, compositional
language to define biological models. Classical process algebras,
however, require to express everything in terms of communications,
a limiting restriction when structured information needs to be
processed. In this book, we tackle this problem using a more
general language and programming it to deal with the domain of
interest. Specifically, we introduce a stochastic extension (sCCP)
of Concurrent Constraint Programming. It is precisely the use of
constraints that gives flexibility and extendibility to the
language, together with the presence of context-dependent
stochastic rates. To prove this, we show how sCCP can be used to
model a wide range of biological systems, from biochemical networks
to the process of folding of a protein, providing evidence that the
use of constraints simplifies the process of modeling and allows to
incorporate external knowledge. Many analysis tools are developed:
stochastic simulation, model checking, ODE-based approximations.
The book can be of interest to researchers working in the field of
computational systems biology.
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