Books > Medicine > Other branches of medicine > Anaesthetics > Pain & pain management
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Hyperalgesia and Allodynia - A Closer Look. Symptoms, Mechanisms and Treatment (Paperback)
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Hyperalgesia and Allodynia - A Closer Look. Symptoms, Mechanisms and Treatment (Paperback)
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Pain and itch are associated with a wide range of injuries and
diseases. Some conditions may have pain and associated symptoms
arising from a discrete cause, such as postoperative and
neuropathic pains or headaches. Chronic itch or pruritus is a
frequent symptom in the general population and in many skin and
systemic diseases. Millions of people on the planet suffer from
acute or chronic pain and itch every year, and the effects of pain
and itch exact a tremendous cost on most countries concerning
health care costs, rehabilitation and lost worker productivity, as
well as the emotional and financial burden it places on patients
and their families. Therefore, the synthesis and development of a
new generation of analgesic drugs with lesser side effects are very
important for society.This book provides an original account of
behavioral, cellular and molecular aspects with important
ramifications for the study of hyperalgesia and allodynia in pain
and itch. It concentrates on the role of transient receptor
potential (TRP) channels functioning in pain and itch states. It
explains how TRP channels work in terms of specified somato-sensory
mechanisms and systems. This book shows that TRP channels are
promising targets for the development of a new group of analgesic
drugs at the periphery and central levels and opportunities for
therapeutic intervention.
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