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Inducible Gene Expression, Volume 1 - Environmental Stresses and Nutrients (Paperback, Softcover reprint of the original 1st ed. 1995)
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Inducible Gene Expression, Volume 1 - Environmental Stresses and Nutrients (Paperback, Softcover reprint of the original 1st ed. 1995)
Series: Progress in Gene Expression
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Cells have evolved multiple strategies to adapt the composition and
quality of their protein equipment to needs imposed by changes in
intra- and extracellular conditions. The appearance of pro teins
transmit ting novel functional properties to cells can be
controlled at a transcrip tional, posttranscriptional,
translational or posttranslational level. Extensive research over
the past 15 years has shown that transcriptional regulation is used
as the predominant strategy to control the production of new
proteins in response to extracellular stimuli. At the level of gene
transcription, the initiation ofmRNA synthesis is used most
frequently to govern gene expression. The key elements controlling
transcription initiation in eukaryotes are activator proteins
(transactivators) that bind in a sequence-specific manner to short
DNA sequences in the of genes. The activator binding sites are
elements of larger proximity control units, ca lied promoters and
enhancers, which bind many distinct proteins. These may synergize
or negatively cooperate with the activators. The do novo binding of
an activator to DNA or, if already bound to DNA, its functional
activation is what ultimately turns on a high-level expression of
genes. The activity of transactivators is controlled by signalling
pathways and, in some cases, transactivators actively partici pate
in signal transduction by moving from the cytoplasm into the
nuc1eus. In this first volume of Inducible Gene Expression, leading
scientists in the field review six eukaryotic transactivators that
allow cells to respond to various extracellular stimuli by the
expression of new proteins."
General
Imprint: |
Birkhauser Boston
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Country of origin: |
United States |
Series: |
Progress in Gene Expression |
Release date: |
March 2012 |
First published: |
1995 |
Editors: |
P.A. Baeuerle
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Dimensions: |
235 x 155 x 15mm (L x W x T) |
Format: |
Paperback
|
Pages: |
284 |
Edition: |
Softcover reprint of the original 1st ed. 1995 |
ISBN-13: |
978-1-4684-6842-7 |
Categories: |
Books >
Medicine >
General issues >
Health systems & services >
General practice
Promotions
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LSN: |
1-4684-6842-1 |
Barcode: |
9781468468427 |
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