This textbook discusses the systemic consequences of cancer,
covering a range of topics from tumor-promoting systemic effects to
the development of cachexia, as summarized in the introductory
chapter 1. Part I of this textbook focuses on tumor-promoting
systemic effects and begins with a chapter on how tumor-derived
extracellular vesicles and particles lay the foundation for future
metastases (Chapter 2). Chapter 3 discusses how metastatic
cells that have colonized the bone impact the local bone
microenvironment, neighboring muscles, and host physiology. Chapter
4 summarizes the available strategies for targeting metastatic
cancer and emphasizes the need to incorporate a systemic view of
the disease. Following this overview of the systemic effects of
cancer progression, Part II of the textbook discusses
cancer-induced cachexia, a debilitating systemic effect of advanced
cancer. Chapters 5-7 examine the key signaling pathways
(interleukin-6/GP130, NF-kB, and muscle proteolysis) that drive the
development of cancer cachexia. Chapters 8 and 9 in Part III of
this textbook explore how toxicities from anti-cancer therapy are
associated with the onset of cachexia in cancer patients, and
provide insight into potential approaches to simultaneously target
both cancer and cachexia. Chapters 10 and 11 (Part IV) conclude
this textbook by outlining promising approaches for the diagnosis
and treatment of cachexia as well as strategies to prevent the
development of cachexia through exercise. An understanding of the
systemic effects of cancer is essential for the design of effective
anti-cancer and anti-cachexia treatment strategies. As such, this
textbook provides key information for both students and scientists
engaged in cancer research and oncology.
General
| Imprint: |
Springer International Publishing AG
|
| Country of origin: |
Switzerland |
| Release date: |
September 2023 |
| First published: |
2022 |
| Editors: |
Swarnali Acharyya
|
| Dimensions: |
235 x 155mm (L x W) |
| Format: |
Paperback
|
| Edition: |
1st ed. 2022 |
| ISBN-13: |
978-3-03-109789-8 |
| Categories: |
Books
|
| LSN: |
3-03-109789-0 |
| Barcode: |
9783031097898 |
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