This text discusses mathematical modelling, analysis and control of the immune system and disease dynamics. The purpose of the book is the practical application of mathematics to immunology and medicine in order to establish a basis for more effective treatment, to provide a tutorial systematic description of how the immune system controls diseases and to present several significant examples such as malignant tumour dynamics and control, and viral hepatitis. The book is multidisciplinary in content, with the intended readers including biomathematicians, biologists and physicists. It combines immunological principles, mathematical models, computer simulations and methods of analysis.

Sparked by demands inherent to the mathematical study of pollution, intensive industry, global warming, and the biosphere, Adjoint Equations and Perturbation Algorithms in Nonlinear Problems is the first book ever to systematically present the theory of adjoint equations for nonlinear problems, as well as their application to perturbation algorithms. This new approach facilitates analysis of observational data, the application of adjoint equations to retrospective study of processes governed by imitation models, and the study of computer models themselves. Specifically, the book discusses:
Principles for constructing adjoint operators in nonlinear problems
Properties of adjoint operators and solvability conditions for adjoint equations
Perturbation algorithms using the adjoint equations theory for nonlinear problems in transport theory, quasilinear motion, substance transfer, and nonlinear data assimilation
Known results on adjoint equations and perturbation algorithms in nonlinear problems
This groundbreaking text contains some results that have no analogs in the scientific literature, opening unbounded possibilities in construction and application of adjoint equations to nonlinear problems of mathematical physics.

Beginning his work on the monograph to be published in English, this author tried to present more or less general notions of the possibilities of mathematics in the new and rapidly developing science of infectious immunology, describing the processes of an organism's defence against antigen invasions. The results presented in this monograph are based on the construc tion and application of closed models of immune response to infections which makes it possible to approach problems of optimizing the treat ment of chronic and hypertoxic forms of diseases. The author, being a mathematician, had creative long-Iasting con tacts with immunologists, geneticist, biologists, and clinicians. As far back as 1976 it resulted in the organization of a special seminar in the Computing Center of Siberian Branch of the USSR Academy of Sci ences on mathematical models in immunology. The seminar attracted the attention of a wide circle of leading specialists in various fields of science. All these made it possible to approach, from a more or less united stand point, the construction of models of immune response, the mathematical description of the models, and interpretation of results."

The volume investigates the interconnections between the Italian Jewish worlds and wider European and Mediterranean circles, situating the Italian Jewish experience within a transregional and transnational context mindful of the complex set of networks, relations, and loyalties that characterized Jewish diasporic life. Preceded by a methodological introduction by the editors, the chapters address rabbinic connections and ties of communal solidarity in the early modern period, and examine the circulation of Hebrew books and the overlap of national and transnational identities after emancipation. For the twentieth century, this volume additionally explores the Italian side of the Wissenschaft des Judentums; the role of international Jewish agencies in the years of Fascist racial persecution; the interactions between Italian Jewry, JDPs and Zionist envoys after Word War II; and the impact of Zionism in transforming modern Jewish identities.

New statements of problems arose recently demanding thorough ana lysis. Notice, first of all, the statements of problems using adjoint equations which gradually became part of our life. Adjoint equations are capable to bring fresh ideas to various problems of new technology based on linear and nonlinear processes. They became part of golden fund of science through quantum mechanics, theory of nuclear reactors, optimal control, and finally helped in solving many problems on the basis of perturbation method and sensitivity theory. To emphasize the important role of adjoint problems in science one should mention four-dimensional analysis problem and solution of inverse problems. This range of problems includes first of all problems of global climate changes on our planet, state of environment and protection of environ ment against pollution, preservation of the biosphere in conditions of vigorous growth of population, intensive development of industry, and many others. All this required complex study of large systems: interac tion between the atmosphere and oceans and continents in the theory of climate, cenoses in the biosphere affected by pollution of natural and anthropogenic origin. Problems of local and global perturbations and models sensitivity to input data join into common complex system."

Why are some countries more willing and able than others to engage in climate change mitigation? The Domestic Politics of Global Climate Change compiles insights from experts in comparative politics and international relations to describe and explain climate policy trajectories of seven key actors: Brazil, China, the European Union, India, Japan, Russia, and the United States. Using a common conceptual framework, the authors find that the scope for a more ambitious climate policy is limited by stable material parameters such as energy resource endowments and accumulated infrastructural investments. Within that scope, governmental supply of mitigation policies seems to meet (or even exceed) societal demand for climate policy change in most cases. Given the important roles that the seven actors play in addressing global climate change, the book's in-depth comparative analysis will help readers assess the prospects for a new and more effective international climate agreement for 2020 and beyond. Students and scholars of environmental politics and the climate and environmental policy fields will find the new conceptual framework and empirical case studies of great value. The book's up-to-date information and analyses will also interest energy sector practitioners and climate and energy policymakers. Contributors: S. Aamodt, S. Andresen, G. Bang, M. Iguchi, A. Korppoo, A. Luta, T. Rauken, J.B. Skjaerseth, I. Stensdal, S. Tankha, A. Underdal

The financial and economic crisis in Europe is not over, and the radically opposing strategies on how to proceed has only increased the complexity of problems in the region, revealing the shortcomings of the EU's architecture. The European Union, perhaps for the first time in its history of more than seventy years, is being perceived as a threat to the financial and monetary stability of the world. A Global Perspective on the European Economic Crisis explores the connection between internal EU actions and institutions and the external factors that influence the ongoing response to the European crisis. With a unique collection of international and interdisciplinary essays, this book considers the complex macroeconomic and challenging political landscape of Europe, looking at how and why the European Union is untenable in its current state. The chapters outline what should be done to make the common currency area more resilient, and explain why external events are particularly problematic for the EU, ultimately offering suggestions for what Europeans should do in order to avoid harmful internal consequences. This volume confronts the causes of the crisis' persistence, its economic and political consequences, and the impact of more recent events and policy decisions. It will be of interest to researchers and policy-makers keen to understand the EU relations and the influence of international organizations in the European economic crisis.

Sparked by demands inherent to the mathematical study of pollution, intensive industry, global warming, and the biosphere, Adjoint Equations and Perturbation Algorithms in Nonlinear Problems is the first book ever to systematically present the theory of adjoint equations for nonlinear problems, as well as their application to perturbation algorithms. This new approach facilitates analysis of observational data, the application of adjoint equations to retrospective study of processes governed by imitation models, and the study of computer models themselves. Specifically, the book discusses: Principles for constructing adjoint operators in nonlinear problems Properties of adjoint operators and solvability conditions for adjoint equations Perturbation algorithms using the adjoint equations theory for nonlinear problems in transport theory, quasilinear motion, substance transfer, and nonlinear data assimilation Known results on adjoint equations and perturbation algorithms in nonlinear problems This groundbreaking text contains some results that have no analogs in the scientific literature, opening unbounded possibilities in construction and application of adjoint equations to nonlinear problems of mathematical physics.

This book presents new original numerical methods that have been developed to the stage of concrete algorithms and successfully applied to practical problems in mathematical physics. The book discusses new methods for solving stiff systems of ordinary differential equations, stiff elliptic problems encountered in problems of composite material mechanics, Navier-Stokes systems, and nonstationary problems with discontinuous data. These methods allow natural paralleling of algorithms and will find many applications in vector and parallel computers.

This book presents new original numerical methods that have been developed to the stage of concrete algorithms and successfully applied to practical problems in mathematical physics. The book discusses new methods for solving stiff systems of ordinary differential equations, stiff elliptic problems encountered in problems of composite material mechanics, Navier-Stokes systems, and nonstationary problems with discontinuous data. These methods allow natural paralleling of algorithms and will find many applications in vector and parallel computers.

The financial and economic crisis in Europe is not over, and the radically opposing strategies on how to proceed has only increased the complexity of problems in the region, revealing the shortcomings of the EU's architecture. The European Union, perhaps for the first time in its history of more than seventy years, is being perceived as a threat to the financial and monetary stability of the world. A Global Perspective on the European Economic Crisis explores the connection between internal EU actions and institutions and the external factors that influence the ongoing response to the European crisis. With a unique collection of international and interdisciplinary essays, this book considers the complex macroeconomic and challenging political landscape of Europe, looking at how and why the European Union is untenable in its current state. The chapters outline what should be done to make the common currency area more resilient, and explain why external events are particularly problematic for the EU, ultimately offering suggestions for what Europeans should do in order to avoid harmful internal consequences. This volume confronts the causes of the crisis' persistence, its economic and political consequences, and the impact of more recent events and policy decisions. It will be of interest to researchers and policy-makers keen to understand the EU relations and the influence of international organizations in the European economic crisis.

This book covers all the relevant areas in the laryngology, from basic science to disorders and diseases to in-clinic procedures and the future of laryngology. It is helpful for those who want to learn more about the larynx, its disorders, and therapeutic interventions.

The volume investigates the interconnections between the Italian Jewish worlds and wider European and Mediterranean circles, situating the Italian Jewish experience within a transregional and transnational context mindful of the complex set of networks, relations, and loyalties that characterized Jewish diasporic life. Preceded by a methodological introduction by the editors, the chapters address rabbinic connections and ties of communal solidarity in the early modern period, and examine the circulation of Hebrew books and the overlap of national and transnational identities after emancipation. For the twentieth century, this volume additionally explores the Italian side of the Wissenschaft des Judentums; the role of international Jewish agencies in the years of Fascist racial persecution; the interactions between Italian Jewry, JDPs and Zionist envoys after Word War II; and the impact of Zionism in transforming modern Jewish identities.

New statements of problems arose recently demanding thorough ana lysis. Notice, first of all, the statements of problems using adjoint equations which gradually became part of our life. Adjoint equations are capable to bring fresh ideas to various problems of new technology based on linear and nonlinear processes. They became part of golden fund of science through quantum mechanics, theory of nuclear reactors, optimal control, and finally helped in solving many problems on the basis of perturbation method and sensitivity theory. To emphasize the important role of adjoint problems in science one should mention four-dimensional analysis problem and solution of inverse problems. This range of problems includes first of all problems of global climate changes on our planet, state of environment and protection of environ ment against pollution, preservation of the biosphere in conditions of vigorous growth of population, intensive development of industry, and many others. All this required complex study of large systems: interac tion between the atmosphere and oceans and continents in the theory of climate, cenoses in the biosphere affected by pollution of natural and anthropogenic origin. Problems of local and global perturbations and models sensitivity to input data join into common complex system."

Beginning his work on the monograph to be published in English, this author tried to present more or less general notions of the possibilities of mathematics in the new and rapidly developing science of infectious immunology, describing the processes of an organism's defence against antigen invasions. The results presented in this monograph are based on the construc tion and application of closed models of immune response to infections which makes it possible to approach problems of optimizing the treat ment of chronic and hypertoxic forms of diseases. The author, being a mathematician, had creative long-Iasting con tacts with immunologists, geneticist, biologists, and clinicians. As far back as 1976 it resulted in the organization of a special seminar in the Computing Center of Siberian Branch of the USSR Academy of Sci ences on mathematical models in immunology. The seminar attracted the attention of a wide circle of leading specialists in various fields of science. All these made it possible to approach, from a more or less united stand point, the construction of models of immune response, the mathematical description of the models, and interpretation of results."

Practical Laryngology is an invaluable guide to laryngology. It covers all the relevant areas in the field, from basic science to disorders and diseases to in-clinic procedures and the future of laryngology.In an easy-to-read format, the book discusses a wide variety of topics including neurological diseases of the larynx, swallowing disorders, laryngeal trauma, stenosis, reflux, acute infections, inflammatory disorders, paediatrics, benign vocal cord lesions and dysplastic lesions. Colour drawings, clinical photographs, and imaging support the text throughout, making it an excellent reference to help the clinician find information quickly and easily. Essential information is presented in a succinct and readable style, making it vital for higher trainees preparing for their final exit examinations and for consultants both in general ENT and the subspecialty of laryngology. This book is the ultimate guide for those wanting to learn more about the larynx, its disorders, therapeutic interventions, and other challenges which may impact patients and their families.