This volume provides a much needed, historically accurate narrative of the development of theories of space up to the beginning of the eighteenth century. It studies conceptions of space that were implicitly or explicitly entailed by ancient, medieval and early modern representations of the cosmos. The authors reassess Alexandre Koyre's groundbreaking work From the Closed World to the Infinite Universe (1957) and they trace the permanence of arguments to be found throughout the Middle Ages and beyond. By adopting a long timescale, this book sheds new light on the continuity between various cosmological representations and their impact on the ontology and epistemology of space. Readers may explore the work of a variety of authors including Aristotle, Epicurus, Henry of Ghent, John Duns Scotus, John Wyclif, Peter Auriol, Nicholas Bonet, Francisco Suarez, Francesco Patrizi, Giordano Bruno, Libert Froidmont, Marin Mersenne, Pierre Gassendi, Gottfried Wilhelm Leibniz and Samuel Clarke. We see how reflections on space, imagination and the cosmos were the product of a plurality of philosophical traditions that found themselves confronted with, and enriched by, various scientific and theological challenges which induced multiple conceptual adaptations and innovations. This volume is a useful resource for historians of philosophy, those with an interest in the history of science, and particularly those seeking to understand the historical background of the philosophy of space.

The future place of medicines in health care is both exciting and uncertain. With an aging population, an increasing number of chronic sick, a growing range of treatment options and a developing European market, the one certainty is that medication patterns will change radically over the next 15 years or so. How the future might look, in terms of quality, volume and cost of pharmacotherapy, is the subject of this report. Four scenarios for the future are set out, all of which take account of already visible trends. Sobriety in sufficiency envisages rational and restrained consumption patterns. Risk of avoidance is dominated by fears of iatrogenic harm and hence minimal drug use. The central feature of Technology on demand, in contrast, is confidence in technological progress. Free market unfettered, finally, is marked by a Europe without frontiers and minimal state intervention. The reader is encouraged to reflect without preconceptions on the future of medicines in health care. No ready-made answers are offered; rather, a wealth of information and analysis is provided which serves to underpin decision making and policy development, not just by central government but also by every institution concerned with the role of medicines in health care.