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The term "autoimmunity" has been used to categorize a number of
different diseases of unknown etiology. The term as applied to many
of these diseases would probably be interpreted best as
"autoreactivity," as the clinical phenotypes are often
characterized by an inflammatory-like accumulation of activated
cells of the immune system at sites of obvious damage of normal
cells and/or tissue. The reasons as to why an immune system should
attack itself are far from clear, although the association with
specific infectious diseases in genetically susceptible people
remains perhaps our best lead. The input of the biotechnological
revolution has enabled us to attempt to readdress many of the
fundamental questions raised by clinical and serological
associations with autoimmune disease. The ability to dissect the
immune response to these infectious agents which are associated
with autoimmune features (as well as the facility to identify new
agents, e. g. HIV), in addition to the ability to clone and
sequence immune response genes, has enabled a much better
understanding, at least of the complexity of "autoimmunity" to be
gleaned. This volume contains the chapters that summarize the
plenary presentations given at The Impact of Biotechnology on
AUTOIMMUNI1Y meeting in Florence, Italy in June 1993. They cover
all aspects from pathogenesis to treatment. The association with
infectious diseases and autoimmunity is comprehensively covered by
David Isenberg who reviews major issues, such as the association of
autoantibodies appearing after infectious disease and antibacterial
antibodies associated with autoimmune disease.
The term "autoimmunity" has been used to categorize a number of
different diseases of unknown etiology. The term as applied to many
of these diseases would probably be interpreted best as
"autoreactivity," as the clinical phenotypes are often
characterized by an inflammatory-like accumulation of activated
cells of the immune system at sites of obvious damage of normal
cells and/or tissue. The reasons as to why an immune system should
attack itself are far from clear, although the association with
specific infectious diseases in genetically susceptible people
remains perhaps our best lead. The input of the biotechnological
revolution has enabled us to attempt to readdress many of the
fundamental questions raised by clinical and serological
associations with autoimmune disease. The ability to dissect the
immune response to these infectious agents which are associated
with autoimmune features (as well as the facility to identify new
agents, e. g. HIV), in addition to the ability to clone and
sequence immune response genes, has enabled a much better
understanding, at least of the complexity of "autoimmunity" to be
gleaned. This volume contains the chapters that summarize the
plenary presentations given at The Impact of Biotechnology on
AUTOIMMUNI1Y meeting in Florence, Italy in June 1993. They cover
all aspects from pathogenesis to treatment. The association with
infectious diseases and autoimmunity is comprehensively covered by
David Isenberg who reviews major issues, such as the association of
autoantibodies appearing after infectious disease and antibacterial
antibodies associated with autoimmune disease.
This 1996 volume reviewed advances in the field of human tumour
immunology, particularly in relation to the potential for immune
intervention in preventing or treating tumours. The editors and
contributors, all prominent workers in the field, survey advances
in the understanding of the relationship between the cancer cell
and the immune response at the time of publication. Chapters review
in depth the function of immune surveillance and mechanisms of
tumour immunity, the role of T lymphocytes and oncogenes in the
immune response to cancer, and the potential for immunotherapy of
cancer. Areas of tumour immunology that were new at the time of
this book's publication are presented, including progress in the
development of tumour vaccines with particular reference to
melanoma. The volumes in this series are intended for a wide
audience of clinicians and researchers with an interest in the
applications of biomedical science to the understanding and
management of cancer.
This 1996 volume reviewed advances in the field of human tumour
immunology, particularly in relation to the potential for immune
intervention in preventing or treating tumours. The editors and
contributors, all prominent workers in the field, survey advances
in the understanding of the relationship between the cancer cell
and the immune response at the time of publication. Chapters review
in depth the function of immune surveillance and mechanisms of
tumour immunity, the role of T lymphocytes and oncogenes in the
immune response to cancer, and the potential for immunotherapy of
cancer. Areas of tumour immunology that were new at the time of
this book's publication are presented, including progress in the
development of tumour vaccines with particular reference to
melanoma. The volumes in this series are intended for a wide
audience of clinicians and researchers with an interest in the
applications of biomedical science to the understanding and
management of cancer.
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