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This book, the proceedings of Falk Symposium No. 104, organized in
collaboration with the Society of Mucosal Immunology, and held in
Saarbrucken, Germany, March 5-7 1998, is centered around the
immunological mechanisms of mucosal protection and their
disturbances leading to intestinal inflammation and destruction.
This is a rapidly expanding field involving recent knowledge of
basic immunology and cell biology as well as clinical observations.
The conference and this book summarize very recent data in this
field and suggest strategies for future research and clinical
applications, and will be of interest to both basic scientists and
clinicians.
Despite recent advances, the pathogenesis and therapy of various
forms of chronic inflammatory diseases of the gastrointestinal
tract remains problematical. Especially threatening is the possible
complication of the development of a malignant growth, but the role
of the chronic inflammatory process in this is not known. Three
examples are: H. pylori-induced gastritis is associated with
gastric lymphomas and carcinomas; there is an increased incidence
of intestinal T-cell lymphomas in tropical sprue; and chronic
inflammatory bowel diseases, particularly ulcerative colitis, are
associated with an increased incidence of carcinoma. In this book,
the Proceedings of Falk Symposium No. 81, held in Berlin, November
3-5, 1994, an extensive exchange of information and opinions
between international experts yields a state-of-the-art consensus
on practical procedures in diagnostics, prophylaxis and therapy.
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