Dr. Reuben provides a timely update to the topic of HCC, which was last covered in 2011. The highly respected authors in his issue address advances in imaging for diagnosis, surgical resection and liver transplantation, and local and systemic therapy. The breadth of the topic is covered, with articles devoted to histopathology, classification and staging, and screening and detection.

Dr. Adrian Reuben updates one of the most highly requested topics in liver disease by inviting highly distinguished authors to address the important aspects of diagnosis and treatment of hepatocelluar carcinoma. State-of-the-art issues are addressed, including the role of oncogenic viruses, molecular and genetic guidelines, and screening and staging. Dr. Reuben, himself, concludes the issue with an important article on an agorithmic approach to diagnosis and treatment: Resect, Ablate, Replace or Intoxicate?