Twenty-five years ago, micro- and nanotechnology were barely in their infancy. Today, technological advancements at the lower end of the nanoscale have radically changed the field of medicine, allowing for innovative and more personalized approaches to numerous pathologies. The initial cascade of advancements was triggered by the herculean efforts of a few pioneers in the field. Dr. Mauro Ferrari is one such visionary; his work over the past two decades has set the stage for medical innovation through nanotechnology. Written by world-renowned experts in the field, this book pays tribute to Dr. Mauro Ferrari's vast contribution to the field of nanotechnology and nanomedicine. It covers the multifaceted and fundamental aspects of biomedical research, including technological innovation, ethics, patient advocacy, and clinical translation, all areas where Dr. Ferrari's contribution has been and continue to be fundamental. Additionally, it presents recent advances in micro- and nanotechnologies. Chapter 2 and Chapters 9 through 27 were originally published in Biomedical Microdevices in the Topical Collection "Biomedical Micro-Nanotechnologies toward Translation"