The book analyses the relationship between ecosystem services, green and blue infrastructures (GBI) and spatial planning in Italy. It provides insights on the opportunities and challenges in the adoption of an ecosystem services (ES)-based approach for Spatial Planning exploring methods and techniques for the design of GBI strategies. Nowadays, there is an advance in ES knowledge and a recognition of the benefits of GBI for the quality of human life and biodiversity conservation. The main challenge remains how this knowledge could be integrated into the planning process and how it could guide the decision-making process towards sustainable development for contemporary cities. The book collects innovative Italian experiences providing important considerations for operationalizing the ES concept and highlighting different disciplinary attitudes and methodological approaches with the common goal to enhance human well-being.