This primer has been designed as a self-instructional text which serves to introduce the reader to both the principles of statistical modelling of covariance structures and to the use of the EQS software package. It is divided into three parts - the first covering the basic ideas and language of covariance structure modelling together with an introduction to the EQS package. The second section covers a wide variety of models suitable for cross-sectional and longitudinal data and the final section discusses a wide variety of practical problems. This book should be of interest to researchers in psychology, sociology and medicine who use the EQS software; applied and consultant statisticians.

About 8000 clinical trials are undertaken annually in all areas of medicine, from the treatment of acne to the prevention of cancer. Correct interpretation of the data from such trials depends largely on adequate design and on performing the appropriate statistical analyses. In this book, the statistical aspects of both the design and analysis of trials are described, with particular emphasis on recently developed methods of analysis.