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This book integrates recent advances in molecular and cell biology
of hematopoietic stem cells (HSC) with developments in clinical
research in stem cell-based therapy-providing an up-to-date review
of novel cytokines and cellular components; animal models; cell
preparation, selection, and collection; minimal residual disease
and purging; expansion of progenitor cells; allogeneic and
autologous transplantation; cellular gene and immunotherapy; and
more. Examines key areas for treatment with HSC, including
ambulatory care and monitoring, regimen-related toxicities,
immunodeficiency and immunization, infection, chronic
graft-versus-host and disease, secondary malignancies, and
long-term quality of life. Covering stem cell pool regulation and
the complex interplay of extrinsic and intrinsic events,
Hematopoietic Stem Cell Transplantation summarizes current
understanding and development of clinical allogeneic HSC
transplantation discusses the use of allogeneic transplantations
with reduced conditioning regimen or mini-transplantation considers
various strategies for mobilization of HSCs from peripheral blood
(PB) of normal donors details detection of bone marrow
contamination by tumor cells and removal procedures focuses on
efforts to increase the ex vivo transduction efficiency of human
HSCs with retroviral vectors explores the effects of growth factor
administration and leukapheresis on PB stem cell donors shows the
impact of CD34+ cell isolation and the relevance of expansion of
HSC from bone marrow for clinical use reveals how minimal residue
disease detection assays are crucial for tracking the clinical
significance of infused tumor cells employs automated fluorescence
image cytometry to study early HSC behavior following seeding
Incorporating contributions from over 90 researchers who cite more
than 2180 references to encourage continued study,
This book integrates recent advances in molecular and cell biology
of hematopoietic stem cells (HSC) with developments in clinical
research in stem cell-based therapy-providing an up-to-date review
of novel cytokines and cellular components; animal models; cell
preparation, selection, and collection; minimal residual disease
and purging; expansion of progenitor cells; allogeneic and
autologous transplantation; cellular gene and immunotherapy; and
more. Examines key areas for treatment with HSC, including
ambulatory care and monitoring, regimen-related toxicities,
immunodeficiency and immunization, infection, chronic
graft-versus-host and disease, secondary malignancies, and
long-term quality of life. Covering stem cell pool regulation and
the complex interplay of extrinsic and intrinsic events,
Hematopoietic Stem Cell Transplantation -summarizes current
understanding and development of clinical allogeneic HSC
transplantation -discusses the use of allogeneic transplantations
with reduced conditioning regimen or mini-transplantation
-considers various strategies for mobilization of HSCs from
peripheral blood (PB) of normal donors -details detection of bone
marrow contamination by tumor cells and removal procedures -focuses
on efforts to increase the ex vivo transduction efficiency of human
HSCs with retroviral vectors -explores the effects of growth factor
administration and leukapheresis on PB stem cell donors -shows the
impact of CD34+ cell isolation and the relevance of expansion of
HSC from bone marrow for clinical use -reveals how minimal residue
disease detection assays are crucial for tracking the clinical
significance of infused tumor cells -employs automated fluorescence
imagecytometry to study early HSC behavior following seeding
Incorporating contributions from over 90 researchers who cite more
than 2180 references to encourage continued study, Hematopoietic
Stem Cell Transplantation is a blue-chip reference for
hematologists, hematopathologists, oncologists, cytotherapists,
transplantation immunologists, and molecular biologists.
Dies ist ein Open Access Buch. Wir haben immer mehr Alte, immer
weniger Kinder. Dank wissenschaftlicher Fortschritte verlangert
sich die Lebenserwartung standig. Erkenntnisse aus der
Naturwissenschaft in der post-genomischen AEra deuten darauf, dass
diese Entwicklung trotz der Zunahme altersassoziierter Krankheiten
und Behinderungen noch nicht am Ende angekommen ist. Droht diese
Flut von Alten, Rentnern und "Konsumenten des Lebens" zum Verlust
des Zusammenhalts der Gesellschaft zu fuhren? Nach der
Bestandsaufnahme der jungsten Errungenschaften der Forschung hat
das interaktive Symposium sich mit den Chancen und Gefahren der
"gewonnenen Jahre" auseinandergesetzt. Die Referentinnen und
Referenten sind herausragende Vertreter der Biologie und Medizin.
Meinungsbildner der Geisteswissenschaften und Persoenlichkeiten aus
der Politik kamen ebenfalls zu Wort.Dies ist ein Open-Access-Buch.
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