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Breast and prostate cancers are both hormone-dependent, at least in
some stages of their progression. Hormonal manipulation represents
an important therapeutic approach. Although most of breast and
prostate cancers initially respond to hormone therapy, most tumors
reinitiate to growth. Finally, hormone-resistant and metastatic
breast and prostate cancers may develop. Thus, the challenge is the
dissection of mechanisms by which steroid receptor signaling
pathways continue to influence cell growth and invasiveness.
Compelling evidence indicates that steroid hormones elicit
non-genomic responses in extra-nuclear compartment of target cells.
In this cellular location, steroid-coupled receptors rapidly
recruit signaling effectors or scaffold proteins and activate
multiple pathways leading to proliferation, survival, migration and
invasiveness. The immediate challenge is the dissection of key
events regulating the steroid response of target tissues to prevent
progression and improve treatment of breast and prostate cancers.
Breast and prostate cancers are both hormone-dependent, at least in
some stages of their progression. Hormonal manipulation represents
an important therapeutic approach. Although most of breast and
prostate cancers initially respond to hormone therapy, most tumors
reinitiate to growth. Finally, hormone-resistant and metastatic
breast and prostate cancers may develop. Thus, the challenge is the
dissection of mechanisms by which steroid receptor signaling
pathways continue to influence cell growth and invasiveness.
Compelling evidence indicates that steroid hormones elicit
non-genomic responses in extra-nuclear compartment of target cells.
In this cellular location, steroid-coupled receptors rapidly
recruit signaling effectors or scaffold proteins and activate
multiple pathways leading to proliferation, survival, migration and
invasiveness. The immediate challenge is the dissection of key
events regulating the steroid response of target tissues to prevent
progression and improve treatment of breast and prostate cancers.
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